A Clinical Study to Compare the Impact of Multiple-dose Oral Administration of Macitentan, 10 mg versus 75 mg on Endothelin-1 Clearance, Endothelial Function, and Hemodynamics in Healthy Participants

2023-504643-13-00 Human pharmacology (Phase I) - Other Ended

End 22 Mar 2024 · Status Ended · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 20
Countries 1
Sites 1

Pulmonary Arterial Hypertension

Key facts

Sponsor
Actelion Pharmaceuticals Ltd.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
completed 22 Mar 2024
Decision date (initial)
2024-02-05
Transition trial
No
Low-intervention
No
Rare-disease indication
Yes
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Pulmonary Arterial Hypertension

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Actelion Pharmaceuticals Ltd.

Sponsor organisation
Actelion Pharmaceuticals Ltd.
Address
Gewerbestrasse 16
City
Allschwil
Postcode
4123
Country
Switzerland

Scientific contact point

Organisation
Actelion Pharmaceuticals Ltd.
Contact name
CTIS Point of Contact

Public contact point

Organisation
Actelion Pharmaceuticals Ltd.
Contact name
CTIS Point of Contact

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ended 20 1
Rest of world 0

Investigational sites

France

1 site · Ended
CHU De Rouen
Service de pharmacologie clinique, 1 Rue De Germont, Bp 96031, Rouen Cedex

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-09-28 France Acceptable
2024-01-29
2024-02-05