OPEN LABEL, FOUR-PERIOD, TWO-SEQUENCE, FULLY-REPLICATED, RANDOMIZED, SINGLE DOSE COMPARATIVE STUDY TO ASSESS BIOEQUIVALENCE OF Polypill AAR 100/80/10 mg capsules FIXED DOSE COMBINATION (TEST) VERSUS EQUAL DOSES OF COADMINISTERED Aspirin® N 100mg tablets + Cardyl® 80mg film-coated tablets + Acovil® 10mg tablets (REFERENCE formulations) IN HEALTHY MALE AND FEMALE VOLUNTEERS UNDER FASTING CONDITIONS

2023-505572-30-00 Protocol ARA-BESD-14-FRI/23 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 24 Oct 2023 · End 2 Feb 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol ARA-BESD-14-FRI/23

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 56
Countries 1
Sites 1

Study performed on healthy volunteers

Key facts

Sponsor
Ferrer Internacional S.A.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
24 Oct 2023 → 2 Feb 2024
Decision date (initial)
2023-10-20
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Study performed on healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Ferrer Internacional S.A.

Sponsor organisation
Ferrer Internacional S.A.
Address
Avinguda Diagonal 549
City
Barcelona
Postcode
08029
Country
Spain

Scientific contact point

Organisation
Ferrer Internacional S.A.
Contact name
Gemma Torres Sotodosos

Public contact point

Organisation
Ferrer Internacional S.A.
Contact name
Gemma Torres Sotodosos

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Romania Ended 56 1
Rest of world 0

Investigational sites

Romania

1 site · Ended
3s Pharmacological Consultation & Res. S.R.L.
Clinical Research Department, Str Centru Dn2 92 3, 727046, Cumparatura

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Romania 2023-10-24 2024-02-02 2023-10-24

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-07-04 Romania Acceptable
2023-10-16
2023-10-20