A pivotal, randomized, open-label, two-treatment, two-sequence, four periods, crossover clinical trial to evaluate the bioequivalence of single doses of Test product Sacubitril/Valsartan, film-coated tablets 97 mg/103 mg (Manufacturer: JSC «Farmak», Ukraine) and Reference Entresto®, film-coated tablets 97 mg/103 mg (Novartis Europharm Limited, Ireland) in healthy subjects under fasted conditions

2023-509484-24-00 Protocol FK/SC-VLS/23 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 10 Aug 2024 · End 27 Sep 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol FK/SC-VLS/23

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 36
Countries 1
Sites 1

Healthy

Key facts

Sponsor
Farmak JSC
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
10 Aug 2024 → 27 Sep 2024
Decision date (initial)
2024-05-06
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Farmak JSC

Sponsor organisation
Farmak JSC
Address
Vul. Kyrylivska 63
City
M. Kyiv
Postcode
04080
Country
Ukraine

Scientific contact point

Organisation
Farmak JSC
Contact name
Olena Barbukho

Public contact point

Organisation
Farmak JSC
Contact name
Olena Barbukho

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Poland Ended 36 1
Rest of world 0

Investigational sites

Poland

1 site · Ended
Pharmbiotest Poland Sp. z o.o.
Inpatient Clinical Trials Unit, Ul. Mieszka I 5, 86-300, Grudziadz

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Poland 2024-08-10 2024-09-27 2024-08-10 2024-08-29

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-01-08 Poland Acceptable
2024-04-29
2024-05-06