Bioequivalence of Lenvatinib 10 mg Capsules versus Lenvima® 10 mg Capsules in Healthy Participants Under Fasting Conditions.

2024-512908-19-00 Protocol BLCL-LEN-EU-01 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 9 Sep 2024 · End 12 Dec 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol BLCL-LEN-EU-01

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 30
Countries 1
Sites 1

No medical condition.

Key facts

Sponsor
Bluepharma Industria Farmaceutica S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
9 Sep 2024 → 12 Dec 2025
Decision date (initial)
2024-07-19
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No medical condition.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Bluepharma Industria Farmaceutica S.A.

Sponsor organisation
Bluepharma Industria Farmaceutica S.A.
Address
Sao Martinho Do Bispo
City
Coimbra
Postcode
3045-016
Country
Portugal

Scientific contact point

Organisation
Bluepharma Industria Farmaceutica S.A.
Contact name
Medical Affairs Department

Public contact point

Organisation
Bluepharma Industria Farmaceutica S.A.
Contact name
Medical Affairs Department

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Portugal Ended 30 1
Rest of world 0

Investigational sites

Portugal

1 site · Ended
Blueclinical Investigacao E Desenvolvimento Em Saude Lda.
Medical Management, Rua De Sarmento De Beires 153 0 Floor 3rd Floor, 4250-449, Porto

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Portugal 2024-09-09 2024-09-09 2024-09-20

Oversight and notifications

Regulatory notifications under CTR Articles 38, 52, 53, 54 and 77

Temporary halts 1 · Art. 38 CTR

Temporary halt TH-49746

Halt date
2024-09-20
Member states concerned
Portugal
Publication date
2024-10-03
Reason
Sponsor decision
Explanation
Taking into account the results of the study with the protocol code BLCL-LEN-FDA-01 (a study with the same test product as the BLCL-LEN-EU-01 study) it was decided to halt the study temporarily in order to assess the need for modifications to the study
Benefit-risk balance changed
No
Treatment stopped
No

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-06-05 Portugal Acceptable
2024-07-18
2024-07-19