Therapeutic vaccination: Phase I / II clinical study on patients randomized blinded to the experimental vaccine or placebo regimen. we want to evaluate the safety and the immunogenicity of a vaccine that includes a first administration of the ChAdOx1.tHIVconsvX product and a second one with MVA.tHIVconsvX in HIV-1 positive adults treated early and able to control the infection for a long time.

2024-514581-39-00 Phase I and Phase II (Integrated) - First administration to humans Ongoing, recruitment ended

Start 8 Nov 2023 · Status Ongoing, recruitment ended · 1 EU/EEA countries · 1 sites

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - First administration to humans
Status Ongoing, recruitment ended
Participants planned 33
Countries 1
Sites 1

HIV Infection

Key facts

Sponsor
Ospedale San Raffaele S.r.l.
Participant type
Patients
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Trial duration
8 Nov 2023 → ongoing
Decision date (initial)
2024-08-05
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-514581-39-00
EudraCT number
2019-003102-26

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

HIV Infection

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Ospedale San Raffaele S.r.l.

Sponsor organisation
Ospedale San Raffaele S.r.l.
Address
Via Olgettina 60
City
Milan
Postcode
20132
Country
Italy

Scientific contact point

Organisation
Ospedale San Raffaele S.r.l.
Contact name
Raffaele Dell'Acqua

Public contact point

Organisation
Ospedale San Raffaele S.r.l.
Contact name
Raffaele Dell'Acqua

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Italy Ongoing, recruitment ended 33 1
Rest of world 0

Investigational sites

Italy

1 site · Ongoing, recruitment ended
Ospedale San Raffaele S.r.l.
Ematologia e TMO, Via Olgettina 60, 20132, Milan

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Italy 2023-11-08 2023-11-08 2025-08-13

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-07-12 Italy Acceptable
2024-07-31
2024-08-05