A Randomized, Multicentre, Seamless, Adaptive Phase I/II Study to Determine Safety and Efficacy of RhinoPHAGE-2A cocktail in Patients with Chronic Rhinosinusitis Associated with Staphylococcus aureus Infection

2024-516220-34-00 Protocol Rhinophage-One Phase I and Phase II (Integrated) - First administration to humans Not authorised

Status Not authorised · 1 EU/EEA countries · 2 sites · Protocol Rhinophage-One

Overview

Sponsor-declared trial summary

Phase Phase I and Phase II (Integrated) - First administration to humans
Status Not authorised
Participants planned 600
Countries 1
Sites 2

Chronic Rhinosinusitis associated with Staphylococcus aureus Infection

Key facts

Sponsor
Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Bacterial Infections and Mycoses [C01], Diseases [C] - Otorhinolaryngologic Diseases [C09]
Decision date (initial)
2025-04-22
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Chronic Rhinosinusitis associated with Staphylococcus aureus Infection

VersionLevelCodeTermSystem organ class
27.0 PT 10080060 Chronic rhinosinusitis with nasal polyps 100000004855
20.0 LLT 10075981 Staphylococcus aureus infection 10021881

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu

Sponsor organisation
Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
Address
Ul. Rudolfa Weigla 12
City
Wroclaw
Postcode
53-114
Country
Poland

Scientific contact point

Organisation
Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
Contact name
Co-ordinating Investigator

Public contact point

Organisation
Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
Contact name
Co-ordinating Investigator

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Poland Not authorised 600 2
Rest of world 0

Investigational sites

Poland

2 sites · Not authorised
Uniwersytecki Szpital Kliniczny Im. Jana Mikulicza-Radeckiego We Wroclawiu
Klinika Otolaryngologii, Chirurgii Głowy i Szyi Szpitala, Ul. Borowska 213, 50-556, Wroclaw
Instytut Immunologii I Terapii Doswiadczalnej Im Ludwika Hirszfelda Pan We Wroclawiu
Ośrodek Terapii Fagowej Centrum Medyczne Instytut Immunologii i Terapii Doświadczalnej, Ul. Rudolfa Weigla 12, 53-114, Wroclaw

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-12-31 Poland Not acceptable
2025-04-14
2025-04-22