A study to test whether treatment with BI 770371 in combination with pembrolizumab with or without cetuximab helps people with head and neck cancer compared with pembrolizumab alone

2024-517091-38-00 Protocol 1501-0002 Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 25 Nov 2025 · Status Ongoing, recruiting · 8 EU/EEA countries · 24 sites · Protocol 1501-0002

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 114
Countries 8
Sites 24

Head and neck squamous cell carcinoma

Key facts

Sponsor
Boehringer Ingelheim International GmbH
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
25 Nov 2025 → ongoing
Decision date (initial)
2025-05-28
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-517091-38-00
WHO UTN
U1111-1312-0435

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Head and neck squamous cell carcinoma

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Boehringer Ingelheim International GmbH

Sponsor organisation
Boehringer Ingelheim International GmbH
Address
Binger Strasse 173
City
Ingelheim Am Rhein
Postcode
55216
Country
Germany

Scientific contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Public contact point

Organisation
Boehringer Ingelheim International GmbH
Contact name
CT Disclosure & Data Transparency

Locations

8 EU/EEA countries · 24 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Authorised, recruiting 8 1
France Ongoing, recruiting 5 4
Germany Ongoing, recruiting 6 4
Hungary Ongoing, recruiting 4 3
Italy Authorised, recruiting 6 5
Poland Authorised, recruiting 5 2
Romania Ongoing, recruiting 16 2
Spain Ongoing, recruiting 5 3
Rest of world
Taiwan, Brazil, United States, Korea, Republic of, Moldova, Republic of, Thailand, Mexico, Georgia, Australia, Switzerland, Singapore, Turkey, United Kingdom, Japan
59

Investigational sites

Bulgaria

1 site · Authorised, recruiting
Multispecialty hospital for active treatment Sveta Sofia EOOD
Department of Medical Oncology, Bulevard Bilgariya 104, 1404, Sofiya

France

4 sites · Ongoing, recruiting
Centre Leon Berard
Service d'Oncologie Médicale, 28 Rue Laennec, 69008, Lyon
Centre Oscar Lambret
DRCI, 3 Rue Frederic Combemale, 59000, Lille
Centre Hospitalier Regional De Marseille
Unité de Phase I Oncologie labélisée CLIP, 264 Rue Saint Pierre, 13005, Marseille
Institut Gustave Roussy
DITEP, 114 Rue Edouard Vaillant, 94800, Villejuif

Germany

4 sites · Ongoing, recruiting
Staedtisches Klinikum Braunschweig gGmbH
Medizinische Klinik II, Celler Strasse 38, 38114, Brunswick
Universitaetsklinikum Jena KöR
HNO-Klinik, Am Klinikum 1, Lobeda, Jena
Universitaet Leipzig
Klinik und Poliklinik für HNO-Heilkunde und Plastische Operationen, Liebigstrasse 12, Zentrum-Suedost, Leipzig
Universitaetsklinikum Ulm AöR
für HNO-Heilkunde, Albert-Einstein-Allee 23, Eselsberg, Ulm

Hungary

3 sites · Ongoing, recruiting
Semmelweis University
Internal Medicine and Oncology Clinic, Koranyi Sandor Utca 2/a, Kerulet, Budapest VIII
Clinexpert Kft.
Bugat Pal Hospital, Dozsa Gyorgy Utca 15, 3200, Gyongyos
Orszagos Onkologiai Intezet
Department of Thoracic and Abdominal Tumors and Clinical Pharmacology, Rath Gyorgy Utca 7-9, Kerulet, Budapest XII

Italy

5 sites · Authorised, recruiting
Istituto Romagnolo Per Lo Studio Dei Tumori Dino Amadori IRST S.r.l.
S.C. di Oncologia Medica, Via Piero Maroncelli 40, 47014, Meldola
Centro Ricerche Cliniche Di Verona S.r.l.
Centro Ricerche Cliniche di Verona - Policlinico G.B. Rossi, Piazzale Ludovico Antonio Scuro 10, 37134, Verona
Fondazione IRCCS Istituto Nazionale Dei Tumori
Dipartimento di Medicina-SS Trattamento Tumori Testa e Collo, Via Giacomo Venezian 1, 20133, Milan
Azienda Ospedaliera Universitaria Federico II Di Napoli
UOC Oncologia, Via Sergio Pansini 5, 80131, Naples
I.F.O. Istituti Fisioterapici Ospitalieri
Divisione Oncologia Medica 2, Via Elio Chianesi N 53, 00144, Rome

Poland

2 sites · Authorised, recruiting
Centrum Onkologii Ziemi Lubelskiej Im. Sw. Jana Z Dukli
Oncology, Ul. Dra Kazimierza Jaczewskiego 7, 20-090, Lublin
Narodowy Instytut Onkologii Im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
Oncology clinic clinical outpatient clinic, Ul. Wybrzeze Armii Krajowej 15, 44-102, Gliwice

Romania

2 sites · Ongoing, recruiting
Institutul Oncologic Prof. Dr. Alexandru Trestioreanu Bucuresti
Oncology, Soseaua Fundeni 252, 022328, Bucharest
Institute Of Oncology Prof. Dr. Ion Chiricuta Cluj-Napoca
Medical Oncology, Strada Republicii 34-36, 400015, Cluj-Napoca

Spain

3 sites · Ongoing, recruiting
Hospital Clinico Universitario De Valencia
Servicio de Oncología Médica, Avenida Blasco Ibanez 17, 46010, Valencia
Hospital Universitari Vall D Hebron
Unidad de Investigación en Terapia Molecular (UITM), Passeig De La Vall D'Hebron 119-129, 08035, Barcelona
Hospital Universitario Virgen De La Victoria
xxxx, Campus De Teatinos Sn, Puerto De La Torre, Malaga

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Bulgaria 2026-01-28
France 2025-12-02 2025-12-19
Germany 2025-11-25 2025-12-18
Hungary 2026-03-24 2026-03-31
Italy 2026-03-20
Poland 2026-03-30
Romania 2025-12-23 2026-01-15
Spain 2026-01-09 2026-04-10

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-01-31 Spain Acceptable with conditions
2025-05-22
2025-05-22
2 SUBSTANTIAL MODIFICATION SM-1 2025-08-12 Spain Acceptable
2025-11-17
2025-11-18
3 NON SUBSTANTIAL MODIFICATION NSM-1 2025-11-25 Acceptable
2025-11-17
2025-11-25
4 SUBSTANTIAL MODIFICATION SM-2 2025-11-28 Spain Acceptable
2026-02-10
2026-02-10
5 SUBSTANTIAL MODIFICATION SM-3 2026-03-05 Acceptable 2026-04-20