Comprendo - a Phase Ii Open Label Study for the Comprehensive Analysis of Predictors of the Treatment with Pembrolizumab and Olaparib in Patients with Unresectable or Metastatic HER2 Negative Breast Cancer and a Deleterious Germline Mutation in BRCA12, Atm, BARD1, CHEK2, Fancc, PALB2, RAD51C, RAD51D, SLX4, XRCC2 or a Homologous Recombination Deficiency

Overview

Sponsor-declared trial summary

Key facts

Sponsor

Institut fuer Frauengesundheit GmbH

Participant type

Patients

Age range

18-64 years, 65+ years

Gender

Male and Female

Therapeutic area

Diseases [C] - Neoplasms [C04]

Trial duration

completed 9 Jan 2025

Decision date (initial)

2024-11-28

Transition trial

Yes

Low-intervention

No

Rare-disease indication

No

Vulnerable population

Yes

Funding sources

MSD SHARP & DOHME GMBH

External identifiers

EU CT number

2024-519350-37-00

EudraCT number

2020-001940-25

ClinicalTrials.gov

NCT05033756

Trial design

CTIS Part I — objectives, methods, condition coding

Main objective

Scope: Efficacy, Therapy

To investigate the efficacy of the combination of pembrolizumab and olaparib, as determined by overall response rate (ORR) using RECIST v1.1 criteria (time frame: baseline to 27 weeks).

Secondary objectives 4

1. To investigate the duration of response (DOR) time for the three cohorts.
2. To investigate the progression free survival (PFS) time for the three cohorts.
3. To investigate the overall survival (OS) time for the three cohorts.
4. To investigate the safety and tolerability of pembrolizumab in combination with olaparib.

Conditions and MedDRA coding

patients with unresectable or metastatic HER2 negative breast cancer and a deleterious germline mutation in BRCA 1/2, ATM, BARD1, CHEK2, FANCC, PALB2, RAD51C, RAD51D, SLX4, XRCC2 or a homologous recombination deficiency

Eligibility criteria

Principal inclusion / exclusion criteria as submitted by sponsor

Inclusion criteria 17

1. The participant (or legally acceptable representative if applicable) must provide written informed consent.
2. Male/Female participants must be ≥18 years of age at the day of signing informed consent and must be willing to comply with the study specific procedures.
3. Histologically confirmed metastatic or advanced, unresectable HER2 negative (0, 1+ by IHC or ISH amplified < 2.0) breast cancer which is not eligible for curative treatment.
4. Cohort 1: Germline mutation in BRCA1 or BRCA2 that is predicted to be deleterious (known or predicted to be detrimental/leads to loss of function) irrespective of HRD status.
5. Cohort 2: Germline mutation in ATM, BARD1, CHEK2, FANCC, PALB2, RAD51C, RAD51D, SLX4, XRCC2 that is predicted to be deleterious (known or predicted to be detrimental/leads to loss of function) irrespective of HRD status.
6. Cohort 3: High HRD status and no germline mutation in one of the above mentioned genes of cohort 1 or cohort 2.
7. Cohort 3: Availability of FFPE tumor material for further validation of HRD status (bridging tests).
8. Cohorts 2 and 3: Patients must have been treated with first line chemotherapy, if this chemotherapy is standard of care in this therapy situation
9. Prior platinum in the (neo)adjuvant setting is allowed as long as 12 months from last dose to study entry have elapsed.
10. Participants with hormone receptor positive breast cancer must have exhausted previous combination therapy of CDK4/6 inhibitors with endocrine treatment.
11. Measurable disease based on RECIST v1.1.
12. Provision of a recently obtained (within 12 months before study inclusion) core or excisional biopsy of a tumor lesion. Note: If submitting unstained cut slides, newly cut slides should be submitted to the testing laboratory within 14 days from the date slides are cut.
13. ECOG performance status 0-1.
14. Female participants must have a negative urine or serum pregnancy test within 72 h prior to first dose of trial treatment, no breastfeeding.
15. Female participants of childbearing potential must agree to use sufficient methods of contraception during treatment plus an additional 120 days after the last dose of study medication.
16. Male participants must agree to use sufficient methods of contraception during treatment plus an additional 120 days after the last dose of study medication.
17. Adequate organ function

Exclusion criteria 27

1. Has histologically confirmed HER2 positive (3+ by IHC or ISH amplified ≥ 2.0) breast cancer.
2. Cohorts 1 and 2: germline mutations in BRCA1, BRCA2, ATM, BARD1, CHEK2, FANCC, PALB2, RAD51C, RAD51D, SLX4, XRCC2 that are considered to be non-detrimental (e.g., “variants of uncertain/unknown clinical significance” or “benign polymorphism” etc.).
3. Cohort 3: no high tumor HRD.
4. Rapidly progressive disease which requires combination chemotherapy
5. Current participation in another investigational trial within 4 weeks prior to the first dose of trial treatment
6. Known hypersensitivity to pembrolizumab or olaparib or any of its excipients.
7. Prior systemic anti-cancer therapy within 4 weeks prior to allocation or no recovery from all AEs due to previous therapies to ≤ grade 1, excluding alopecia and ≤ grade 2 peripheral neuropathy.
8. Prior treatment with a checkpoint inhibitor or a PARP inhibitor.
9. No complete recovery from prior surgery or radiotherapy. Starting study treatment is allowed not before 2 weeks after major surgery.
10. Prior malignancy unless curatively treated and disease-free for less than 3 years prior to study entry. Within this timeframe, prior adequately treated non-melanoma skin cancer, transitional cell carcinoma, carcinoma in situ of the prostate, of the cervix, of the breast or in situ or stage I grade 1 endometrial cancer is eligible.
11. Uncontrolled brain metastases (Participants with previously treated brain metastases may participate provided they are radiologically stable, i.e. without evidence of progression for at least 4 weeks (note that the assessment of the brain metastases should be performed during study screening for this purpose), clinically stable and without requirement of steroid treatment for at least 14 days prior to first dose of study treatment).
12. Live vaccination within 30 days prior to study entry.
13. Has active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is allowed
14. Has an active infection requiring systemic therapy.
15. Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis.
16. Known history of the following infections: Human Immunodeficiency Virus (HIV), Acute or chronic Hepatitis B or Hepatitis C, Active Tuberculosis
17. Resting ECG indicating uncontrolled, potentially reversible cardiac conditions, as judged by the investigator (e.g., unstable ischemia, uncontrolled symptomatic arrhythmia, congestive heart failure, QTcF prolongation >500 ms, electrolyte disturbances, etc.), or patients with congenital long QT syndrome.
18. Patients with myelodysplastic syndrome (MDS) or acute myeloid leukaemia (AML) or with features suggestive of MDS/AML.
19. Preexisting use of known strong CYP3A inhibitors (e.g. itraconazole, telithromycin, clarithromycin, protease inhibitors boosted with ritonavir or cobicistat, indinavir, saquinavir, nelfinavir, boceprevir, telaprevir) or moderate CYP3A inhibitors (e.g. ciprofloxacin, erythromycin, diltiazem, fluconazole, verapamil). The required washout period prior to starting trial treatment is 2 weeks.
20. Preexisting use of known strong (e.g. phenobarbital, enzalutamide, phenytoin, rifampicin, rifabutin, rifapentine, carbamazepine, nevirapine and St John’s Wort ) or moderate CYP3A inducers (e.g. bosentan, efavirenz, modafinil). The required washout period prior to starting trial treatment is 5 weeks for enzalutamide or phenobarbital and 3 weeks for other agents.
21. Previous allogenic bone marrow transplant or double umbilical cord blood transplantation (dUCBT).
22. Poor medical risk due to a serious, uncontrolled medical disorder, nonmalignant systemic disease or active, uncontrolled infection; any condition that interferes with pembrolizumab or olaparib treatment.
23. Unability to swallow or gastrointestinal disorders with reduced absorption of olaparib.
24. Psychiatric or substance abuse disorders.
25. A woman of childbearing potential who has a positive urine pregnancy test within 72 hours prior to inclusion. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
26. Participants being pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of trial treatment.
27. Any other condition in opinion of the investigator that would interfere with applied systemic treatment or other trial procedures

Endpoints

Primary and secondary outcome measures (English text)

Primary endpoints 1

1. Overall Response confirmed complete response (CR) or partial response (PR) per RECIST v1.1 criteria (time frame: baseline to 27 weeks).

Secondary endpoints 4

1. duration of response (DOR) defined as the time between the date of first response (CR or PR) to the date of first tumor progression
2. progression free survival (PFS) defined as the time between the date of study entry and the first date of progression or death
3. overall survival (OS) defined as the time between the date of study entry and the date of death due to any cause
4. incidence of adverse events, serious adverse events, fatal events

Investigational products

Investigational medicinal products (IMPs), comparators, placebo, auxiliary

Test 3

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Institut fuer Frauengesundheit GmbH

Sponsor organisation

Institut fuer Frauengesundheit GmbH

Address

Hindenburgstrasse 50, Innenstadt Innenstadt

City

Erlangen

Postcode

91054

Country

Germany

Scientific contact point

Organisation

Institut fuer Frauengesundheit GmbH

Contact name

Comprendo Study Management

Public contact point

Organisation

Institut fuer Frauengesundheit GmbH

Contact name

Comprendo Study Management

Locations

1 EU/EEA country · 7 investigational sites

By country

Investigational sites

Results and documents

Annex IV summary of results, Annex V layperson summary, and all documents registered in CTIS for this trial

Summary of results Art. 37(4) CTR

Layperson summary Annex V

Documents 6 files

Public protocol annexes, IB summaries, regulatory submissions and post-authorisation documents registered in CTIS.

Application history

1 submissions — initial application plus substantial / non-substantial modifications