Dose Escalation and Dose Expansion Study of BBO-10203 in Subjects with Advanced Solid Tumors

2024-519445-29-00 Protocol TBBO10203-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 2 Oct 2025 · Status Ongoing, recruiting · 3 EU/EEA countries · 25 sites · Protocol TBBO10203-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 408
Countries 3
Sites 25

Solid Tumors

Key facts

Sponsor
Theras Inc.
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
2 Oct 2025 → ongoing
Decision date (initial)
2025-04-04
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

External identifiers

EU CT number
2024-519445-29-00
ClinicalTrials.gov
NCT06625775

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Solid Tumors

VersionLevelCodeTermSystem organ class
21.0 LLT 10049280 Solid tumour 10029104

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Theras Inc.

Sponsor organisation
Theras Inc.
Address
256 East Grand Avenue Suite 104
City
South San Francisco
Postcode
94080-4811
Country
United States

Scientific contact point

Organisation
Theras Inc.
Contact name
CTIS Contact Point

Public contact point

Organisation
Theras Inc.
Contact name
CTIS Contact Point

Locations

3 EU/EEA countries · 25 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 29 6
Italy Authorised, recruitment pending 16 8
Spain Ongoing, recruiting 46 11
Rest of world
Korea, Republic of, Australia, United States, Brazil
317

Investigational sites

France

6 sites · Ongoing, recruiting
Institut De Cancerologie De L Ouest
Medical Oncology, Boulevard Jacques Monod, 44805, Saint-Herblain Cedex
Centre Leon Berard
Medical Oncology, 28 Rue Laennec, 69008, Lyon
Institut Gustave Roussy
Department of Therapeutic Innovation and Early Trials, 114 Rue Edouard Vaillant, 94800, Villejuif
Institut Regional Du Cancer De Montpellier
Medical Oncology, 208 Avenue Des Apothicaires, 34298, Montpellier Cedex 5
Institut Curie
Medical Oncology, 35 Rue Dailly, 92210, Saint-Cloud
Institut Bergonie
Medical Oncology, 180 R De Saint Genes, 229 Cours De L Argonne, Bordeaux

Italy

8 sites · Authorised, recruitment pending
Fondazione IRCCS Istituto Nazionale Dei Tumori
Phase 1 Unit, Via Giacomo Venezian 1, 20133, Milan
Azienda Ospedaliero Universitaria Delle Marche
Dpt Internal Medicine- SOD Clinic Oncology, Via Conca 71, 60126, Ancona
Istituto Europeo Di Oncologia S.r.l.
Development of New Drugs for Innovative Therapies, Via Giuseppe Ripamonti 435, 20141, Milan
IRCCS Istituto Nazionale Tumori Fondazione Pascale
Oncology division, Via Mariano Semmola 52, 80131, Naples
Azienda Ospedaliero Universitaria Careggi
Clinical Oncology Departmental Unit, Largo Giovanni Alessandro Brambilla 3, 50134, Florence
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
UOC Phase 1, Largo Francesco Vito 1, 00168, Rome
Centro Di Riferimento Oncologico Di Aviano
Medical Oncology and Cancer Prevention, Via Franco Gallini 2, 33081, Aviano
Ospedale San Raffaele S.r.l.
Oncology Medicine Unit, Via Olgettina 60, 20132, Milan

Spain

11 sites · Ongoing, recruiting
Hospital Universitario Quironsalud Madrid
Oncology, Calle De Diego De Velazquez 1, 28223, Pozuelo De Alarcon
Hospital Universitari Arnau De Vilanova De La Gerencia Territorial De Lleida
Oncology, Avinguda De L'alcalde Rovira Roure 80, 25196, Lleida
Hospital Beata Maria Ana
Oncology, Calle Del Doctor Esquerdo No. 83, 28007, Madrid
Hospital Universitario Fundacion Jimenez Diaz
Oncology, Avenida De Los Reyes Catolicos 2, 28040, Madrid
Hospital Quironsalud Barcelona
Oncology, Placa D'alfonso Comin 5-7, 08023, Barcelona
Hospital Universitari Vall D Hebron
Oncology, Passeig De La Vall D'Hebron 119-129, 08035, Barcelona
Hospital Hm Nou Delfos
Oncology, Avinguda De Vallcarca 151, 08023, Barcelona
Hospital Universitario Y Politecnico La Fe
Oncology, Avenida Fernando Abril Martorell 106, 46026, Valencia
Institut Catala D'oncologia
Oncology, Avinguda De La Gran Via De L'hospitalet 199-203, 08908, L'hospitalet De Llobregat
Fundacion Instituto Valenciano De Oncologia
Oncology, Calle Professor Beltran Baguena 8, 46009, Valencia
Hospital Universitario 12 De Octubre
Oncology, Avenida De Cordoba Sn, 28041, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2025-10-02 2025-12-29
Spain 2025-10-02 2026-02-11

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-12-11 Spain Acceptable
2025-04-03
2025-04-04
2 NON SUBSTANTIAL MODIFICATION NSM-1 2025-04-24 Spain Acceptable
2025-04-03
2025-04-24
3 SUBSTANTIAL MODIFICATION SM-2 2025-10-06 Spain Acceptable
2025-12-19
2025-12-19
4 SUBSEQUENT ADDITION OF MSC APP-4 2026-02-05 2026-04-29