A Phase 1, Open-Label, Dose-escalation Clinical Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Patients with Injectable Solid Tumors.

2024-520258-39-00 Protocol TILT-T115 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 2 sites · Protocol TILT-T115

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 39
Countries 1
Sites 2

Solid Tumors

Key facts

Sponsor
TILT Biotherapeutics Oy
Participant type
Patients
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Decision date (initial)
2024-12-20
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-520258-39-00
EudraCT number
2020-001778-31
ClinicalTrials.gov
NCT04695327

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Solid Tumors

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

TILT Biotherapeutics Oy

Sponsor organisation
TILT Biotherapeutics Oy
Address
Tukholmankatu 8b
City
Helsinki
Postcode
00290
Country
Finland

Scientific contact point

Organisation
TILT Biotherapeutics Oy
Contact name
Claudia Kistler

Public contact point

Organisation
TILT Biotherapeutics Oy
Contact name
Claudia Kistler

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Finland Authorised, recruitment pending 39 2
Rest of world 0

Investigational sites

Finland

2 sites · Authorised, recruitment pending
Docrates Oy
Clinical, Saukonpaadenranta 2, 00180, Helsinki
HUS-Yhtymae
Clinical, Haartmaninkatu 4, 00290, Helsinki

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-12-16 Finland Acceptable
2024-12-20
2024-12-20