Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of ANB033

2024-520409-38-00 Protocol ANB033-101 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 14 Nov 2025 · Status Ongoing, recruiting · 3 EU/EEA countries · 9 sites · Protocol ANB033-101

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 143
Countries 3
Sites 9

Eosinophilic esophagitis (EoE)

Key facts

Sponsor
Anaptysbio Inc.
Participant type
Patients, Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Immune System Diseases [C20]
Trial duration
14 Nov 2025 → ongoing
Decision date (initial)
2025-12-18
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Eosinophilic esophagitis (EoE)

VersionLevelCodeTermSystem organ class
20.1 PT 10064212 Eosinophilic oesophagitis 100000004856
28.0 LLT 10007864 Celiac disease 10017947

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Anaptysbio Inc.

Sponsor organisation
Anaptysbio Inc.
Address
10770 Wateridge Circle Suite 210
City
San Diego
Postcode
92121-5801
Country
United States

Scientific contact point

Organisation
Anaptysbio Inc.
Contact name
Mark Rigby, M.D.

Public contact point

Organisation
Anaptysbio Inc.
Contact name
Anne Severtson

Locations

3 EU/EEA countries · 9 investigational sites

By country

CountryMS statusPlanned subjectsSites
Finland Ongoing, recruiting 3 1
Germany Ongoing, recruiting 10 5
Netherlands Ongoing, recruiting 12 3
Rest of world
New Zealand, Australia, Canada, United Kingdom, United States
118

Investigational sites

Finland

1 site · Ongoing, recruiting
Pirkanmaan hyvinvointialue
Tutkimusvastaanotto, Biokatu 10, FM 3, 2. krs., Elamanaukio 2, 33520, Tampere

Germany

5 sites · Ongoing, recruiting
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz KöR
N/A, Langenbeckstrasse 1, Oberstadt, Mainz
Universitaetsklinikum Erlangen AöR
N/A, Ulmenweg 18, Innenstadt, Erlangen
University Medical Center Hamburg-Eppendorf
N/A, Martinistrasse 52, Eppendorf, Hamburg
Universitaet Leipzig
Bereich Gastroenterologie, Liebigstrasse 20, Zentrum-Suedost, Leipzig
Klinikum der Technischen Universitaet Muenchen (TUM Klinikum)
N/A, Ismaninger Strasse 22, Au-Haidhausen, Munich

Netherlands

3 sites · Ongoing, recruiting
CTC Netherlands B.V.
N/A, Hanzeplein 1, 9713 GZ, Groningen
Albert Schweitzer Ziekenhuis
Maag-, Darm- en Leverziekten, Albert Schweitzerplaats 25, 3318 AT, Dordrecht
Amsterdam UMC Stichting
Dept. of Gastroenterology, De Boelelaan 1117, 1081 HV, Amsterdam

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Finland 2026-01-29 2026-03-18
Germany 2026-03-04 2026-03-18
Netherlands 2025-11-14 2026-02-10

Application history

6 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-05-26 Netherlands Acceptable
2025-07-23
2025-07-24
2 SUBSTANTIAL MODIFICATION SM-1 2025-08-13 Netherlands Acceptable
2025-08-15
2025-08-18
3 SUBSEQUENT ADDITION OF MSC APP-3 2025-10-07 Acceptable
2025-08-15
2025-12-18
4 SUBSEQUENT ADDITION OF MSC APP-4 2025-10-07 2026-01-13
5 SUBSTANTIAL MODIFICATION SM-2 2025-12-19 Netherlands Acceptable 2026-01-08
6 SUBSTANTIAL MODIFICATION SM-3 2026-02-27 Netherlands Acceptable
2026-05-06
2026-05-15