A study to assess the safety and immunogenicity of a therapeutic hepatitis B virus vaccine, in healthy adults (RUBY).

2025-521169-28-00 Protocol AVX37-102 Human pharmacology (Phase I) - First administration to humans Ongoing, recruitment ended

Start 6 May 2025 · Status Ongoing, recruitment ended · 1 EU/EEA countries · 1 sites · Protocol AVX37-102

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruitment ended
Participants planned 16
Countries 1
Sites 1

Hepatitis B

Key facts

Sponsor
AstriVax
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Virus Diseases [C02]
Trial duration
6 May 2025 → ongoing
Decision date (initial)
2025-04-28
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Hepatitis B

VersionLevelCodeTermSystem organ class
20.1 PT 10008910 Chronic hepatitis B 100000004862

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

AstriVax

Sponsor organisation
AstriVax
Address
Gaston Geenslaan 3 Box 4
City
Leuven
Postcode
3001
Country
Belgium

Scientific contact point

Organisation
AstriVax
Contact name
Mathieu Peeters

Public contact point

Organisation
AstriVax
Contact name
Hanne Callewaert

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Belgium Ongoing, recruitment ended 16 1
Rest of world 0

Investigational sites

Belgium

1 site · Ongoing, recruitment ended
Universitair Ziekenhuis Gent
Center for Vaccinology (CEVAC), Corneel Heymanslaan 10, 9000, Gent

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Belgium 2025-05-06 2025-05-06 2025-06-04

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-02-25 Belgium Acceptable
2025-04-28
2025-04-28