Single dose oral bioequivalence study of Cladribine 10 mg Tablets and Mavenclad® 10 mg tablets (Cladribine) in healthy adult human subjects under fed conditions

2025-522252-74-00 Protocol CPO25001 Human pharmacology (Phase I) - Bioequivalence study Ended

End 7 May 2026 · Status Ended · 1 EU/EEA countries · 2 sites · Protocol CPO25001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 40
Countries 1
Sites 2

No therapeutic indication in the current trial with healthy volunteers.

Key facts

Sponsor
PharOS Pharmaceutical Oriented Servises Ltd., CCDRD Cooperative Clinical Drug Research and Development AG
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male
Therapeutic area
Not possible to specify
Trial duration
completed 7 May 2026
Decision date (initial)
2025-10-08
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No therapeutic indication in the current trial with healthy volunteers.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

PharOS Pharmaceutical Oriented Servises Ltd.

Sponsor organisation
PharOS Pharmaceutical Oriented Servises Ltd.
Address
Lesvou Street End, Thesi Loggos Industrial Zone Thesi Loggos Industrial Zone
City
Metamorfossi
Postcode
144 52
Country
Greece

Scientific contact point

Organisation
PharOS Pharmaceutical Oriented Servises Ltd.
Contact name
Project Manager

Public contact point

Organisation
PharOS Pharmaceutical Oriented Servises Ltd.
Contact name
Project Manager

CCDRD Cooperative Clinical Drug Research and Development AG

Sponsor organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Address
Dahlwitz, Lindenallee 70, Dahlwitz-Hoppegarten Lindenallee 70 Dahlwitz-Hoppegarten
City
Hoppegarten
Postcode
15366
Country
Germany

Scientific contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Project Manager

Public contact point

Organisation
CCDRD Cooperative Clinical Drug Research and Development AG
Contact name
Project Manager

Locations

1 EU/EEA country · 2 investigational sites

By country

CountryMS statusPlanned subjectsSites
Bulgaria Ended 40 2
Rest of world 0

Investigational sites

Bulgaria

2 sites · Ended
Clinic of Clinical Pharmacology and Therapeutics UMHAT 'Tsaritsa Ioanna-ISUL' EAD
Clinic of Clinical Pharmacology and Therapeutics, 8 'Bialo more' Str., 1527, Sofia
Bed space for short term stay at Diagnostic & Consultative Centre 'Ascendent' Ltd.
Diagnostic & Consultative Centre 'Ascendent' Ltd., 47 'Bacho Kiro' str., 1202, Sofia

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-06-30 Bulgaria Acceptable
2025-10-06
2025-10-08