Multiple-Ascending Doses of 2-Methoxyestradiol in Healthy Non-Pregnant Female Participants.

2025-523419-12-00 Protocol BLCL-2ME-02 Human pharmacology (Phase I) - Other Ended

Start 15 Oct 2025 · End 15 May 2026 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol BLCL-2ME-02

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 60
Countries 1
Sites 1

No medical condition.

Key facts

Sponsor
Laboratorios Leon Farma S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Female
Therapeutic area
Not possible to specify
Trial duration
15 Oct 2025 → 15 May 2026
Decision date (initial)
2025-09-29
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

No medical condition.

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Laboratorios Leon Farma S.A.

Sponsor organisation
Laboratorios Leon Farma S.A.
Address
Calle La Vallina S/N, Poligono Industrial Navatejera Poligono Industrial Navatejera
City
Villaquilambre
Postcode
24193
Country
Spain

Scientific contact point

Organisation
Laboratorios Leon Farma S.A.
Contact name
Enrico Colli

Public contact point

Organisation
Laboratorios Leon Farma S.A.
Contact name
Enrico Colli

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Portugal Ended 60 1
Rest of world 0

Investigational sites

Portugal

1 site · Ended
Blueclinical Investigacao E Desenvolvimento Em Saude Lda.
Medical Management, Rua De Sarmento De Beires 153 0 Floor 3rd Floor, 4250-449, Porto

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Portugal 2025-10-15 2025-10-15

Application history

4 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-08-14 Portugal Acceptable
2025-09-25
2025-09-29
2 NON SUBSTANTIAL MODIFICATION NSM-1 2026-01-21 Portugal Acceptable
2025-09-25
2026-01-21
3 SUBSTANTIAL MODIFICATION SM-1 2026-03-02 Portugal Acceptable
2026-04-10
2026-04-13
4 NON SUBSTANTIAL MODIFICATION NSM-2 2026-05-27 Portugal Acceptable
2026-04-10
2026-05-27