A Phase 1, Open-Label Study to Assess the Absorption, Distribution, Metabolism, and Excretion, Including the Mass Balance, of a Single Oral Dose of [14C-VAFIDEMSTAT in Healthy Male Participants

2025-524832-20-00 Protocol CL12-ORY-2001 Human pharmacology (Phase I) - Other Authorised, recruitment pending

Status Authorised, recruitment pending · 1 EU/EEA countries · 1 sites · Protocol CL12-ORY-2001

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Authorised, recruitment pending
Participants planned 8
Countries 1
Sites 1

Healthy volunteers

Key facts

Sponsor
Oryzon Genomics S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male
Therapeutic area
Not possible to specify
Decision date (initial)
2026-04-30
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Oryzon Genomics S.A.

Sponsor organisation
Oryzon Genomics S.A.
Address
Avinguda De Sant Ferran 74, Poligono Industrial Cornella De Llobregat Poligono Industrial Cornella De Llobregat
City
Cornella De Llobregat
Postcode
08940
Country
Spain

Scientific contact point

Organisation
Oryzon Genomics S.A.
Contact name
Chief Scientific Officer

Public contact point

Organisation
Oryzon Genomics S.A.
Contact name
Chief Scientific Officer

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Authorised, recruitment pending 8 1
Rest of world 0

Investigational sites

Netherlands

1 site · Authorised, recruitment pending
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2026-03-24 Netherlands Acceptable
2026-04-30
2026-04-30
2 SUBSTANTIAL MODIFICATION SM-1 2026-05-19 Netherlands Acceptable 2026-05-28