Esketamine — Drug Intelligence | 12 EU Trials

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12 Registered trials

8 Recruiting

1 Completed trials

12 Sponsors

10 Countries

Phase III

Phase II

Phase IV

Phase III: 7 Phase II: 2 Phase IV: 3

Oversight events:

3 serious breaches 1 temporary halt across 1 trial

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Indications tested

Cardiac arrest 1 Status epilepticus 1 Schizophrenia 1

Sponsors using this IMP

Academisch Ziekenhuis Leiden 1 Academisch Ziekenhuis Maastricht 1 Amsterdam UMC 1 Amsterdam UMC Stichting 1 Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevilla 1 Janssen - Cilag International 1 Leiden University Medical Center 1 Universitair Medisch Centrum Groningen 1 Universitair Medisch Centrum Utrecht 1 Universiteit Twente 1 University Medical Center Utrecht 1 Vaestra Goetalandsregionen 1

All trials

12 total

A randomised, controlled trial to investigate the effect of a four/six week intensified pharmacological treatment for schizophrenia, major d… Not authorised

2022-502185-24-00 Phase III 4 countries University Medical Center Utrecht
RESET-TRD; a Randomised trial on oral ESketamine compared to Electroconvulsive Therapy for patients with Treatment Resistant Depression Pending

2024-517485-42-00 Phase III 1 country Universitair Medisch Centrum Groningen
Pain Relief via Mouthwash or Intravenous Infusion in Mouth Inflammation after Chemotherapy Pending

2025-522545-22-00 Phase II 1 country Amsterdam UMC Stichting
A study for adolescents who are depressed and thinking of suicide Recruiting

2024-518615-19-00 Phase III 4 countries Janssen Cilag International
Comparison of esketamine with an antidepressant versus aripiprazole with an antidepressant, in the refractory major depression disorder in e… Recruiting

2024-512672-34-00 Phase III 1 country Fundacion Publica Andaluza Para La Gestion De La Investigacion En Salud De Sevil…
FORE-PAIN trial Recruiting

2022-500176-63-00 Phase III 1 country Amsterdam UMC
Treatment of ELectroencephalographic STatus epilepticus After cardiopulmonary Resuscitation-2 (TELSTAR-2): a multicenter randomised clinical… Recruiting

2024-516068-27-01 Phase III 2 countries Universiteit Twente
Esketamine nasal spray (Spravato) for the treatment of therapy-resistant bipolar depression. An open-label pilot trial. Recruiting

2023-508125-27-00 Phase II 1 country Academisch Ziekenhuis Leiden
A randomised, controlled trial to investigate the effect of a six-week intensified pharmacological treatment for major depressive disorder c… Recruiting

2023-506617-21-00 Phase III 5 countries Universitair Medisch Centrum Utrecht
Effects of an Opioid Sparing Care Pathway for Patients undergoing Obesity Surgery Recruiting

2023-505934-86-00 Phase IV 1 country Vaestra Goetalandsregionen
The effect of perioperative intravenous s-ketamine on acute and chronic postoperative craniotomy pain compared to placebo Recruiting

2024-514020-16-00 Phase IV 1 country Academisch Ziekenhuis Maastricht
Hypoxic ventilatory response (HVR): Effect of Esketamine Ended

2023-504229-37-00 Phase IV 1 country Leiden University Medical Center

Showing 1–12 of 12 trials

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