Trametinib

25 trials 15 recruiting LOncology Orphan designation

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25 Registered trials

15 Recruiting

7 Completed trials

20 Sponsors

17 Countries

Phase II

Phase I/II

Phase III: 2 Phase II: 16 Phase I/II: 4 Phase IV: 2 Phase I (FiH): 1

Oversight events:

1 serious breach 4 temporary halts 2 urgent safety measures 1 unexpected event across 4 trials

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Indications tested

Non-small cell lung cancer 2 BRAF gene mutation 1 Colorectal cancer 1

Sponsors using this IMP

Novartis Pharma AG 3 Region Hovedstaden 3 Oslo University Hospital HF 2 Akershus University Hospital 1 Bristol-Myers Squibb Services Unlimited Company 1 C4 Therapeutics Inc. 1 Cancer Trials Ireland 1 Celgene Corp. 1 Centre Leon Berard 1 Erasca Inc. 1 Erasmus Universitair Medisch Centrum Rotterdam (Erasmus MC) 1 Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Stichting 1

All trials — page 2

25 total

Precision therapy versus standard therapy in Acute Myeloid Leukaemia and Myelodysplastic syndrome in elderly (PALM) – a phase II randomized … Ended

2023-509092-16-00 Phase II 1 country Akershus University Hospital

Showing 25–25 of 25 trials

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