Phase I/II – First Administration

443 trials 187 recruiting

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PIGMENT – PDE6A gene therapy for retinitis pigmentosa Ended

2024-517924-20-00 PDE6A-linked Retinitis Pigmentosa 2019-09-24
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specifi… Ended

2024-511798-31-00 KRAS p.G12C Mutant Advanced Solid Tumors 2019-05-31
GEN1046 Safety Trial in Patients With Malignant Solid Tumors Ended

2023-509059-15-00 Malignant solid tumors: endometrial carcinoma (EC), uro 2019-04-30
A clinical gene therapy study with hematopoietic stem cells for the treatment of patients suffering from a malignant neoplasm of the central… Ended

2023-510299-29-00 Glioblastoma multiforme 2019-03-13
A study to test IMGN632 in adults with CD123-positive Acute Myeloid Leukemia and other CD123 positive Hematologic cancers. Ended

2024-514195-40-00 Acute Myeloid Leukemia and other blood cancers 2019-02-28
Study to test the safety and how well patients with severe hemophilia A respond to treatment with BAY 2599023 (DTX 201), a drug therapy that… Ended

2023-505827-29-00 Hemophilia A 2018-10-30
A Phase 1/2, Open-Label, Dose-Escalation Trial of GEN3013 in Patients with Relapsed, Progressive or Refractory B-Cell Lymphoma Ended

2023-504802-12-00 Lymphoma of B-cell origin 2018-05-16
Gene therapy study with autologous hematopoietic stem cells for patients affected by MPS-IH Ended

2024-514870-29-00 Mucopolysaccharidosis type I Hurler 2018-05-14
Talquetamab (GPRC5D and CD3 antibody) in Relapsed or Refractory Multiple Myeloma Ended

2023-504581-29-00 Multiple myeloma 2018-04-26
A Study of Glofitamab (RO7082859) and Atezolizumab or Polatuzumab Vedotin (Plus A Single Pretreatment Dose of Obinutuzumab) in Adult Patient… Ended

2023-505222-34-00 Relapsed/refractory (r/r) B-cell Non-Hodgkin’s Lymphoma 2018-04-23
An Open label Study of Teclistamab in Subjects with Relapsed and Refractory Multiple Myeloma Ended

2023-503438-40-00 Relapsed/Refractory Multiple Myeloma 2017-10-05
A Phase 1/2 study on the effects of LOXO-292 (study drug) in patients with advanced solid tumors. Ended

2023-507702-13-00 Male or female patients age 12 years or older with a lo 2017-09-22
A Study to Assess Safety, Effectiveness, Pharmacokinetics, and Pharmacodynamics of RO7112689 in Healthy Volunteers and Patients with Paroxys… Ended

2023-506287-14-00 Paroxysmal nocturnal hemoglobinuria (PNH) 2017-04-21
A First-in-Human, Open-label, Phase 1/2 Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of JNJ-63723… Ended

2023-506144-16-00 Advanced Stage Solid Tumors 2016-12-06
A Phase Ib-II Study of tazemetostat (EPZ-6438) in newly diagnosed Diffuse Large B Cell Lymphoma (DLBCL) or high risk Follicular Lymphoma (FL… Ended

2024-515846-18-00 Newly diagnosed Diffuse Large B Cell Lymphoma 2016-09-19
A study of AZD2962, an IRAK4 inhibitor, in Participants with Haematologic Neoplasms Halted

2025-520786-44-00 Myelodysplastic syndromes 2025-10-21
A Phase 1/2 Study to Assess the Safety, Pharmacokinetics, and Efficacy of Daily Intravenous of AB8939 in patients with Relapsed/Refractory A… Halted

2024-516641-39-00 Acute Myeloid Leukemia 2024-12-02
Application of antiCD19 CAR T lymphocytes for the treatment of adult patients with B-cell acute lymphoblastic leukemia with resistance, rela… Halted

2024-519808-27-00 B-cell acute lymphoblastic leukemia. with resistance, r 2023-12-19
To Investigate whether the combination of molidustat and an IDH1 inhibitor (ivosidenib) effectively inhibits leukaemia cells in patients wit… Halted

2024-514051-15-00 Adult patients with relapsed or refractory IDH1-mutated 2023-07-10
A Phase I/II study of DYP688 treatment alone in patients with eye cancer and other types of cancers of the skin and mucosal membranes in the… Halted

2023-509451-14-00 Metastatic uveal melanoma 2022-11-01
A research study looking at a new treatment for patients with advanced cancer, to investigate different doses of the experimental study drug… Halted

2024-514588-24-00 Acute Myeloid Leukaemia (AML) 2021-09-27
A trial to learn how safe AZD0022 is, how well it works, and how it moves throughout the body over time in adults with tumors that have a KR… Ended

2024-516699-14-00 Non Small Cell Lung Cancer Colorectal Cancer Pancreatic 2025-04-23
A Study of ASP1570 Taken by Itself, or ASP1570 Taken Together with Either Pembrolizumab, Standard Therapies, or Both, in Adults with Solid T… Ended

2023-505084-37-00 Advanced Solid Tumors 2025-03-17
A study to evaluate S227928 as a Single Agent and in Combination with Venetoclax in Patients with R/R AML, MDS/AML, or CMML Ended

2024-514356-33-00 "Patients with Relapsed/Refractory (R/R) Acute Myeloid 2025-02-11