Phase I/II – First Administration

443 trials 187 recruiting

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A Phase 1/Phase 2 Trial to Evaluate Safety, Immunogenicity and PSA Response of VTP-850 Prostate Cancer Immunotherapeutic in Men with Biochem… Not authorised

2023-504066-39-00 Prostate Cancer
A Phase 1/2, First-in-Human, Open-Label, Dose Escalation and Expansion Study of STAR0602, a Selective T Cell Receptor (TCR) - targeting, Bif… Not authorised

2023-505334-10-00 Unresectable, Locally Advanced, or Metastatic Solid Tum
CELL-BASED IMMUNOTHERAPY FOR TREATMENT OF TRIPLE NEGATIVE BREAST CANCER STAGES II AND III Not authorised

2023-506019-16-01 TRIPLE NEGATIVE BREAST CANCER
A Randomized, Multicentre, Seamless, Adaptive Phase I/II Study to Determine Safety and Efficacy of RhinoPHAGE-2A cocktail in Patients with C… Not authorised

2024-516220-34-00 Chronic Rhinosinusitis associated with Staphylococcus a
A Phase I First-in-Human Dose Escalation Trial to Evaluate the Safety and Efficacy of ARI-HER2 (HER2BBz CAR-T Cells) in Patients with HER2Po… Not authorised

2025-521052-35-00 Patients with HER2Positive Advanced Breast Cancer
Clinical trial to assess the safety and tolerability of TP-122A for the treatment of ventilator-associated pneumonia. Not authorised

2023-508825-29-00 Ventilator-Associated Pneumonia
A Phase I-IIa Trial on the Safety and Preliminary Effectiveness of Intramyocardial Injection of Allogeneic Cardiac Atrial Stem Cells for the… Not authorised

2024-517031-51-00 Heart Failure
A study to find how well LY3884961 works and how safe it is in participants with Parkinson’s disease Not authorised

2024-519587-40-00 Parkinson’s Disease with at Least One GBA1 Mutation
A Phase 1/2 Clinical Study of Intravenous Gene Transfer with an AAVrh10 Vector Expressing GALC in Krabbe Subjects Receiving Hematopoietic St… Not authorised

2023-504900-28-00 Krabbe Disease
The ALPINE trial: a phase 1-2 study of intra-arterial [177Lu]Lu-PSMA-I&T for progressive or recurrent intracranial adult type diffuse gliom… Pending

2023-504696-24-00 Glioma (diffuse astrocytoma, oligodendroglioma or gliob
CELL-BASED IMMUNOTHERAPY FOR TREATMENT OF TRIPLE NEGATIVE BREAST CANCER STAGES II AND III Pending

2023-506019-16-03 TRIPLE NEGATIVE BREAST CANCER
A Phase 1/2, First-in-Human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Anti_Tumor Activity of AVZO-02… Pending

2024-517339-30-00 Advanced Solid Tumors
efficacy and safety of the use of regulatory T cells in immune hyperactivation in patients with COVID-19 and/or acute respiratory distress s… Pending

2024-519799-25-00 immune hyperactivation in COVID-19 patients and/or acut
POSITRON EMISSION TOMOGRAPHY/COMPUTED TOMOGRAPHY STUDY FOR SAFETY, TOLERABILITY, BIODISTRIBUTION AND PERFORMANCE OF [68Ga]Ga-DOTA-SIGLEC-9 F… Pending

2024-519864-42-00 active arthritis, vasculitis, pulmonary sarcoidosis
mRNA Therapy to restore lymphatic flow in secondary lymphedema Pending

2024-520149-22-00 Lymphedema
Single-centre, randomised, double-blind, split-face comparative design clinical trial to evaluate the efficacy and safety of the topical for… Pending

2025-521806-16-00 facial melasma
Study of IBI3009 alone or in combination with other therapies for extensive-stage small cell lung cancer Pending

2025-523972-21-00 Extensive-Stage Small Cell Lung Cancer
Phase 1/2 Study of BLU-451 in certain advanced cancers Pending

2022-502527-21-00 Advanced cancers with EGFR Exon20 insertions mutations
DUAL Pending

2023-505453-40-00 Prostate cancer
Allogeneic adipose tissue-derived Mesenchymal stromal cells for the treatment of chronic-active antibody mediated rejection in Kidney transp… Pending

2024-510723-18-00 Chronic active antibody mediated rejection
[18F]-olaparib PET; Molecular imaging of DNA damage response by [18F]-olaparib PET Pending

2024-511962-34-00 Head and neck squamous cell carcinoma (HNSCC)
Guided by Light: Optimizing Surgical Excision of Oral Cancer Using Realtime Fluorescence Imaging Pending

2024-512824-13-01 Oral cancer
LUMC-BOB1-B7-TCR.1 in relapsed and refractory B-cell malignancies Pending

2024-515900-38-00 B-cell Acute Lymphoblastic Leukemia
A trial to learn how safe AZD9793 is, how it moves throughout the body over time, how it affects the body, and how well it works in adults w… Pending

2024-516698-56-00 Hepatocellular Carcinoma