Phase I/II – First Administration

443 trials 187 recruiting

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A Phase 1/2 First-Time-in-Human study of GSK5458514 administered alone or in combination with other anti-cancer agents in participants with … Recruiting

2025-521581-10-00 Neoplasms, Prostate 2026-01-16
A Phase 1/2a Study of UCART20x22 in B-Cell Non-Hodgkin Lymphoma [NatHaLi-01] Recruiting

2022-501607-27-00 Relapsed or refractory B-cell Non-Hodgkin lymphoma 2026-01-06
A Study to Investigate Safety and Effectiveness of CRN09682 in Participants With SST2-Expressing NENs and Other Solid Tumors Recruiting

2025-521672-60-00 Metastatic or locally advanced SST2-positive neuroendoc 2025-12-19
A trial to learn how safe AZD3632 is, how well it works, and how it moves throughout the body over time in adults with acute leukemia and my… Recruiting

2025-521299-76-00 Relapsed or refractory acute leukaemia or Myelodysplast 2025-12-18
A first-in-human study to learn how safe BAY 3713372 is and how it works in participants with MTAP-deleted solid tumors Recruiting

2025-520623-24-00 MTAP-deleted Solid Tumors 2025-11-19
A Phase 1-2, Double-Blind, MAD Study of ION440 in MDS Recruiting

2023-507192-22-00 Methyl CpG binding protein 2 (MECP2) Duplication Syndro 2025-10-24
Evaluation of long-term safety in parkinsonian patients with intracerebroventricular administration of A-dopamine (anaerobic dopamine) - (DI… Recruiting

2025-522261-30-00 Parkinson disease 2025-10-01
Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 Recruiting

2024-518144-20-00 Primary Hyperoxaluria Type 1 (PH1) 2025-09-03
A study to investigate the safety and efficacy of mRNA-3927 in participants with genetically confirmed propionic acidemia Recruiting

2022-502910-10-00 Propionic Acidemia 2025-08-11
A 2-Part, Randomized, Double-Blind, Placebo-Controlled Study in Participants with Duchenne Muscular Dystrophy Amenable to Exon 45 Skipping t… Recruiting

2024-517499-39-00 Duchenne Muscular Dystrophy 2025-07-16
BOLD-100 in Combination with FOLFOX for the Treatment of Advanced Solid Tumours Recruiting

2024-517500-11-00 Colorectal Cancer 2025-07-15
BreAK CRC (001) trial Recruiting

2024-512011-45-00 Unresectable locally advanced or metastatic colorectal 2025-06-17
A Study to Investigate ALE.P02 as Monotherapy in Adult Patients with Selected CLDN1+ Solid Tumors Recruiting

2024-515459-39-00 Advanced or Metastatic Squamous Solid Tumors 2025-05-08
Phase I/II ex vivo gene therapy clinical trial for RDEB using autologous skin equivalent grafts genetically corrected with a COL7A1-encoding… Recruiting

2024-518368-10-00 Recessive dystrophic epidermolysis bullosa (RDEB) 2025-01-29
Clinical trial of MDNA11 (investigational drug) administered alone or in combination with pembrolizumab (immune checkpoint inhibitor) in Pat… Recruiting

2023-507536-21-00 Advanced Solid Tumors 2024-10-04
Kidney cancer Recruiting

2023-505605-16-00 Metastatic Clear Cell Renal Cell Carcinoma (ccRCC) or p 2024-04-24
Study to assess the safety and efficacy of the SpectraCure P18 System Recruiting

2022-502285-24-00 Recurrent prostate cancer 2024-03-01
Safety and effect of mesenchymal derived Extracellular Vesicles in the prevention of Bronchopulmonary Dysplasia in extremely preterm newborn… Recruiting

2022-500293-34-01 Bronchopulmonary Dysplasia 2023-12-28
A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of … Recruiting

2023-504254-35-00 Unresectable locally advanced or metastatic solid tumor 2023-06-20
First in human study of BAY2927088 in participants who have advanced non-small cell lung cancer (NSCLC) with mutations in the genes of epide… Recruiting

2023-503795-24-00 Avanced Non-Small Cell Lung Cancer 2022-09-16
A Phase 1/2/3 Study of UX701 Gene Therapy in Adults with Wilson Disease”. Recruiting

2022-502873-40-00 Wilson disease 2022-06-13
Phase 1/2 dose-escalation study to evaluate the safety, tolerability, and efficacy of a single intravenous infusion of SPK-3006 in adults wi… Recruiting

2023-509303-32-00 Pompe Disease (also known as glycogen storage disease t 2021-10-19
A Phase 1/2 First in Human Study of the Menin-MLL (KMT2A) Inhibitor KO-539 in Patients with Relapsed or Refractory Acute Myeloid Leukemia Recruiting

2023-510509-17-00 Relapsed and/or refractory Acute Myeloid Leukemia 2020-06-17
A prospective multicentre single-arm study in adults to evaluate the safety and preliminary efficacy of the autologous 3D osteogenic implant… Recruiting

2024-517762-42-01 recalcitrant lower limb nonunion 2018-08-02