Phase I/II – First Administration

443 trials 187 recruiting

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A study to investigate the safety and efficacy of ONA-255 in participants with advanced cancer Recruiting

2025-522233-62-00 Advanced cancer; breast cancer; metastatic gastric / ga 2025-12-12
A Phase 1/2 Study of BMS-986482 Alone or Combination Therapy in Participants with Advanced Solid Tumors Recruiting

2024-516602-28-00 Advanced Solid Tumors 2025-11-21
GAIN-CTNNB1: A Phase I/II open-label trial to evaluate the safety, tolerability, and preliminary efficacy of a single intracerebroventricula… Recruiting

2025-522719-40-00 CTNNB1 syndrome 2025-11-21
A Phase Ib/II first-in-human, multicentre, open-label, multiple ascending dose study of S230815 in paediatric participants with KCNT1-relate… Recruiting

2024-513332-17-00 KCNT1-related Developmental and Epileptic Encephalopath 2025-11-19
A First-In-Human, phase I/IIa, open-label trial assessing safety, tolerability, and feasibility of repeated administrations of a novel autol… Recruiting

2025-521227-70-00 Patients with locally advanced or metastatic prostate c 2025-11-13
Trial of THEO-260 in Ovarian Cancer Patients (OCTOPOD) Recruiting

2024-511236-27-00 High grade serous or endometroid ovarian cancer 2025-11-12
Study of ECI830 Single Agent or in Combination in Patients With Advanced HR+/HER2- Breast Cancer and Other Advanced Solid Tumors Recruiting

2024-517281-42-00 Advanced solid tumors 2025-11-12
Monocentric, open-label, single-arm, phase I/II clinical trial to evaluate the use of the ONCOGREEN galenic formulation consisting of indocy… Recruiting

2025-521273-14-00 Solid neoplasms of the digestive system (primary and/or 2025-11-10
A Phase 1/2 Open-Label Rolling-Arm Umbrella Platform Study of Investigational Agents With or Without Pembrolizumab in Participants with PD-1… Recruiting

2023-506384-34-00 Locally advanced or metastatic urothelial carcinoma 2025-11-05
Phase 1/2a study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of SQY51 in Paediatric and Adult Patients with a Genetically… Recruiting

2022-500703-49-01 Duchenne muscular dystrophy 2025-11-05
A phase Ib/II first-in-human imaging study of anti-GD2-800CW in patients with neuroblastoma. Recruiting

2023-507596-22-00 Neuroblastoma 2025-11-05
Effect of TRI-001 in patients with chronic limb threatening ischemia Recruiting

2024-517765-16-00 Patients with Chronic Limb Threatening Ischemia (CLTI) 2025-11-01
Phase I/IIa study to test the safety and efficacy of MSC from umbilical cord tissue (UC-MSC) for the treatment of cartilage damage in the kn… Recruiting

2024-517684-23-00 Cartilage defect of the knee joint 2025-10-23
A Phase 1/2 Study to Assess AMG 732 in Healthy Subjects and Subjects with Thyroid Eye Disease Recruiting

2024-514110-12-00 Thyroid Eye Disease 2025-10-22
A Phase 1/2, Multicenter, Open Label, Dose Escalation and Dose Expansion Study of JK06, a 5T4 Antibody Drug Conjugate, in Patients with Unre… Recruiting

2024-512421-92-00 Unresectable, Locally Advanced or Metastatic Cancer 2025-10-14
Intracochlear application of (Extracellular Vesicle-enriched Secretome Fraction; VSF1.01) for the Reduction of Cochlear Implant Surgery Rela… Recruiting

2024-512498-29-00 hearing loss 2025-09-24
Trial of an investigational drug after the rejection of an allogeneic transplant. Recruiting

2022-503063-15-00 Multiple myeloma. 2025-09-22
Phase I/IIa clinical trial with dose escalation to evaluate safety and efficacy of the infusion of CART84 in relapsed/refractory (R/R) acute… Recruiting

2024-519966-31-00 Relapsed/refractory Acute Lymphoblastic T Leukemia (T-A 2025-09-08
A Phase 1/2, open-label, multicenter, dose-escalation, and dose‑optimization study to evaluate the safety, tolerability, and activity of EIK… Recruiting

2024-520395-99-00 Advanced solid tumors 2025-08-12
Master protocol of TCR-modified T cell therapy targeting HLA-restricted KRAS antigen administered in adult patients with metastatic or local… Recruiting

2024-513900-32-00 Pancreatic Ductal Adenocarcinoma 2025-07-03
RR001, a cell-based gene therapy administered in combination with chemotherapy for the treatment of patients with locally advanced pancreati… Recruiting

2024-516019-26-00 Ductal adenocarcinoma of pancreas 2025-06-25
First-in-Human Study of ADCE-D01 in Soft Tissue Sarcoma (ADCElerate 1) Recruiting

2024-516900-41-00 Soft Tissue Sarcoma 2025-06-24
A Study of SGT-003 Gene Therapy in Duchenne Muscular Dystrophy Recruiting

2024-514501-57-00 Duchenne muscular dystrophy 2025-06-20
A Trial to Learn if REGV131-LNP1265 is Safe and Works to Help the Body Make Clotting Factor in Adult Patients with Hemophilia B Recruiting

2023-507260-40-00 Hemophilia B 2025-06-16