Phase I/II – First Administration

443 trials 187 recruiting

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Phase 1b/2, Multicenter, Open-label, Dose-Expansion Modular Study To Explore the Safety, Tolerability, and Anti-tumor Activity of HER3-DXd m… Recruiting

2023-505925-15-00 Patients with HER2-positive (HER2-pos) (cohort 1) or HE 2024-03-21
A study to assess the safety and efficacy of IPN10200 in adult participants with moderate to severe upper facial lines Recruiting

2024-512782-14-00 Treatment of Moderate to Severe Upper Facial Lines 2024-03-20
A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants with Hearing Loss Due to Otoferlin Pathogenic Var… Recruiting

2024-511342-40-00 Congenital Hearing Loss Secondary to Biallelic Pathogen 2024-03-04
First in Human Study of TOS-358 in Adults with Soid Tumors Recruiting

2023-505346-26-01 9 main solid tumors – colorectal, cervical, endometrial 2024-02-19
Ph1/2 study of AVB-101 in Subjects with Frontotemporal Dementia with Progranulin Mutations (FTD-GRN) Recruiting

2023-509444-10-00 Frontotemporal Dementia With Progranulin Mutations (FTD 2024-02-08
A Phase 1/2 study of Enzomenib (DSP-5336) in Adult Patients with Acute leukemia Recruiting

2022-502741-10-00 Acute Leukemia with Mixed Lineage Leukemia (MLL)-rearra 2024-01-26
FIRST IN-HUMAN STUDY EVALUATING THE EFFECT OF VARIOUS DOSES OF ODM-212 IN SUBJECTS WITH SELECTED ADVANCED SOLID TUMOURS Recruiting

2022-503061-29-00 Neoplasms benign malignant and unspecified (incl cysts 2024-01-22
A study of STX-478 alone and in combination with other anticancer drugs in participants with advanced solid tumors. Recruiting

2023-504807-94-00 Breast Cancer; Advanced solid tumors including but not 2023-12-26
A study to investigate the safety and clinical activity of belantamab for the treatment of multiple myeloma when used as monotherapy and in … Recruiting

2022-501941-63-00 Multiple myeloma 2023-12-13
Phase 1/2 study of mRNA-3705 in participants with Isolated MMA (Extension Study). Recruiting

2022-501997-20-00 participants with isolated methylmalonic acidemia (MMA) 2023-12-01
FIPO23 Phase I/II, multi center, Open Label, First-in-human, Dose Escalation and Expansion study to investigate the Safety, Pharmacokinetics… Recruiting

2023-505266-29-00 Advanced or metastatic solid tumors 2023-11-14
A Modular, Multi-part, Multi-arm, Open-label, Phase I/II Study to Evaluate the Safety and Tolerability of GRWD5769 Alone and in Combination … Recruiting

2023-504845-30-00 Solid malignancies 2023-10-05
A double-blind, placebo-controlled, randomised phase 1/2a study to evaluate the safety, tolerability and pharmacokinetics of single and rep… Recruiting

2023-505778-14-00 Age related hearing loss 2023-09-19
A Dose Escalation and Expansion Study of BGB-16673 in Patients with B Cell Malignancies Recruiting

2022-502157-33-00 B-Cell Malignancies 2023-09-18
A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given with Either Cemiplimab, or Cemiplimab + Fianlimab, … Recruiting

2022-501904-83-00 Ovarian Cancer 2023-09-11
First-in-human, Phase 1/2, open-label, multicenter, dose-escalation and expansion study Recruiting

2022-502645-99-00 MTAP-deleted Advanced or Metastatic Solid Tumors 2023-08-09
A Phase I/II First-In-Human Clinical Trial to Evaluate the Safety, Tolerability and Anti-Tumor Activity of IMA402, a Bispecific T Cell-Engag… Recruiting

2022-503133-54-00 Solid Tumors 2023-08-09
A Phase 1/2 Open Label non randomized Study, multicentric, single arm evaluating the Safety and Efficacy of Gene Therapy of the severe comb… Recruiting

2024-513652-15-00 Severe Combined Immuno-Deficiency (SCID) caused by bial 2023-07-19
A phase 1/2 open-label, multicenter study to assess the safety, pharmacokinetics and anti-tumor activity of GTAEXS617 in patients with advan… Recruiting

2023-508227-13-00 Advanced solid tumors 2023-06-19
Early phase study to evaluate the safety and efficacy of SMART101 to improve transplantation in blood cancers Recruiting

2024-517953-28-00 Treatment in haematopoietic stem cell transplantation 2023-06-07
Phase 1/2 multicenter, open-label, dose-escalation study of IDP-121 in patients with relapsed/refractory hematologic malignancies (CASSANDRA… Recruiting

2024-519194-19-00 Chronic lymphocytic leukemia (CLL) 2023-06-06
CA-4948-101: Open-Label, Dose Escalation and Expansion Trial of Emavusertib (CA-4948) in R/R PCNSL Recruiting

2024-513312-95-00 Part B+C. Primary central nervous system lymphoma (PCNS 2023-05-30
A first-in-human clinical study of PBP1510 in patients with pancreatic cancer. Recruiting

2024-514379-16-00 Advanced and/or metastatic pancreatic adenocarcinoma 2023-04-01
A study of MP0533 in patients with blood cancer. Recruiting

2023-505259-39-00 Acute Myeloid Leukemia (AML) 2023-03-02