Phase I/II – First Administration

443 trials 187 recruiting

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A study on the reactogenicity, safety, immune response, and efficacy of a targeted immunotherapy against HSV in healthy participants aged 18… Ended

2024-510571-37-00 Herpes Simplex 2023-12-06
First-in-human interleukin-15-transpresenting Wilms’ tumor protein 1-targeting autologous dendritic cell vaccination in cancer patients Ended

2024-515296-35-00 Histologically or cytologically confirmed solid tumor o 2023-12-06
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First in-Human, Consecutive-Cohort, Clinical Trial of BI 1910, a Monoclonal Antibody to… Ended

2022-503066-74-00 Advanced solid tumors 2023-12-04
A Phase 1b/2 Study of BMS-986442 with Nivolumab with or without Chemotherapy in Solid Tumors and Non-small Cell Lung Cancer Ended

2022-503108-26-00 Solid Tumor 2023-11-06
A Study of NB003 in Patients With Advanced Malignancies Ended

2022-502401-15-00 Gastrointestinal stromal tumor 2023-10-19
A proof-of-concept study with NVDX3, an osteogenic implant of human allogenic origin, in the treatment of low grade degenerative lumbar spon… Ended

2023-508471-37-00 Low grade degenerative lumbar spondylolisthesis by inte 2023-10-12
Safety and efficacy of GSK Neisseria gonorrhoeae GMMA (NgG) investigational vaccine when administered to healthy adults 18 to 50 years of ag… Ended

2022-500883-37-00 This FTiH-PoC study aims to provide an early evaluation 2023-10-02
A study to investigate safety and efficacy with SAR445514 in participants with relapsed/refractory multiple myeloma (RRMM) and relapsed/refr… Ended

2022-502057-33-00 Relapsed/refractory multiple myeloma 2023-10-02
APTIVATE Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Tuspetinib (HM43239) in Patients with… Ended

2023-503244-14-00 Relapsed or Refractory Acute Myeloid Leukemia (AML) 2023-08-11
A first-in-human proof-of-concept study with NVDX3, an osteogenic implant of human allogenic origin, in the treatment of distal radius fract… Ended

2023-508321-27-00 Distal radius fractures 2023-08-08
Multicentric randomized phase I/IIa trial of the safety and immunogenicity of a therapeutic HPV DC targeting vaccine in patients with Human … Ended

2022-502930-25-00 reduced risk of relapse of HPV-related oropharyngeal sq 2023-07-31
A Multicenter, Open-label Phase 1/2 Study of TYRA 300 in Advanced Urothelial Carcinoma and Other Solid Tumors Ended

2023-507589-22-00 Advanced Urothelial Carcinoma and Other Solid Tumors wi 2023-07-28
A Study of TAK-676 as Single Agent and TAK-676 in Combination With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors Ended

2023-505627-30-00 Solid Neoplasm 2023-07-26
A Phase 1/2, Open-Label, Multicenter Study of KYV-101, an Autologous Fully-Human Anti-CD19 Chimeric Antigen Receptor T-Cell (CD19 CAR T) The… Ended

2024-513329-22-00 Lupus Nephritis 2023-07-20
A Study of TransCon TLR7/8 Agonist With or Without Pembrolizumab in Patients With Advanced or Metastatic Solid Tumors Ended

2024-517150-10-00 Cancer 2023-06-29
A Study to Characterize the Safety, Tolerability, and Preliminary Efficacy of CFT1946 as Monotherapy and Combination Therapy in Subjects Wi… Ended

2022-501618-70-00 BRAF-V600 Mutant Solid Tumors including Melanoma, Non-s 2023-06-27
Study of BGB-A425 and LBL-007 in Combination With Tislelizumab in Advanced Solid Tumors Ended

2022-500694-14-00 Head and Neck Squamous Cell Cancer 2023-06-02
A study to see how well CVGBM vaccine works at different doses and how safe it is in patients who had surgery for glioblastoma or astrocytom… Ended

2022-501423-25-00 Surgically Resected Glioblastoma (GBM) or Astrocytoma w 2023-05-05
A clinical trial to investigate EO4010, a novel cancer vaccine therapy, with an immune checkpoint blocker, in patients with previously treat… Ended

2023-509509-62-00 Patients with unresectable, previously treated locally 2023-05-03
A study to find and confirm the dose and assess the safety, reactogenicity and immune response of a vaccine against influenza in healthy you… Ended

2022-502308-66-00 Healthy volunteers (prevention of influenza infection) 2023-04-27
First-in-human phase I/IIa study investigating inhaled CIS-DPI as add-on treatment in Stage IV NSCLC patients Ended

2022-501183-17-00 Non-Small Cell Lung Cancer 2023-02-23
A clinical study to evaluate mRNA-3705 in Patients with MMA Ended

2022-502492-32-00 Isolated Methylmalonic Acidemia Due to Methylmalonyl-Co 2023-02-03
A first-in-human clinical trial in adult patients with metastatic or recurrent melanoma of a personalised therapy targeting specific mutatio… Ended

2024-513062-19-00 Metastatic or recurrent melanoma 2022-12-22
A Study to Evaluate Safety, Tolerability, and Preliminary Effect of the GEN1053 Antibody on Malignant Solid Tumors as Monotherapy and in Com… Ended

2022-502419-12-00 Malignant Solid Tumors 2022-11-02