Phase I/II – First Administration

443 trials 187 recruiting

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A Multicentre, Open-Label, Single Ascending Dose, Dose-Ranging, Phase I/IIa Study to Evaluate the Safety and Tolerability of an Autologous A… Ended

2024-512579-11-00 Prophylaxis against renal transplant rejection 2021-03-17
GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies Ended

2023-507086-26-00 Relapsed or Refractory Multiple Myeloma (RRMM) Diffuse 2021-03-09
A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors Ended

2024-518529-14-00 Metastatic/advanced soft tissue sarcoma (STS), Merkel c 2021-02-26
Phase I/II trial of S65487 plus azacitidine in acute myeloid leukemia Ended

2023-510051-27-00 Acute Myeloid Leukemia (AML) 2021-02-25
A Phase I/IIb extension study assessing the long-term safety and efficacy of a gene therapy (AAV5-hFIX) previously administered to adult pat… Ended

2024-512603-39-00 Haemophilia B 2021-01-08
Phase I/II, First in Human, Dose Escalation Trial of TL-895 Monotherapy in Subjects with Relapsed/Refractory B-Cell Malignancies and Expansi… Ended

2024-516691-14-00 B Cell Malignancies and Chronic Lymphocytic Leukemia or 2021-01-05
A dose-esalation phase I/II study in patients with RAS-mutated metastatic colorectal cancer to investigate safety and clinical actvitiy of t… Ended

2023-509732-25-00 metastatic colorectal cancer with a proven RAS mutation 2020-07-31
Safety, immunogenicity and preliminary clinical activity study of PDC*lung01 cancer vaccine in NSCLC Ended

2024-517429-24-00 Non-small-cell lung cancer 2020-01-09
REGN5093 in Patients With MET-Altered Advanced Non-Small Cell Lung Cancer Ended

2023-506248-18-00 MET-altered non-small cell lung cancer (NSCLC) 2020-01-07
Botulinum toxin (BOTOX®) to prevent post-operative pancreatic fistula in patients who undergo distal pancreatectomy Ended

2024-517267-23-00 postoperative pancreatic fistulas 2019-11-11
An Early Phase Study with the Drug LOXO-305 in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL… Ended

2023-509270-37-00 Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma 2019-10-10
NeoRay - Phase I/IIa trial of [177Lu]-NeoB in patients with advanced solid tumors and with [68Ga]-NeoB lesion uptake. Ended

2023-507170-41-00 Solid tumors known to overexpress GRPR and with [68Ga]- 2019-07-29
An phase I study of BI 765063 (a monoclonal antibody) as single agent and in combination with BI 754091 (a PD-1) to characterize safety, pha… Ended

2024-519150-37-00 Patients with advanced solid tumour 2019-05-21
A Phase 1/2/3 Study to Evaluate the Safety and Efficacy of a Single Dose of Autologous CRISPR-Cas9 Modified CD34+ Human Hematopoietic Stem a… Ended

2024-516067-83-00 Severe sickle cell disease (SCD) 2019-05-02
"Safety, efficacy, immunogenicity study of GSK Biologicals’ HBV viral vector and adjuvanted proteins vaccine (GSK3528869A) in adult patients… Ended

2023-510020-68-00 Hepatitis B, Chronic 2019-03-18
A Phase I/II Study of NMS-03592088, a FLT3, KIT and CSF1R Inhibitor, in Patients with Relapsed or Refractory AML or CMML Ended

2023-508655-39-00 Acute Myeloid Leukemia (AML) or Chronic Myelomonocytic 2019-02-13
Phase 1 / 2 study of amcenestrant (SAR439859) single agent and in combination with other anti-cancer therapies in postmenopausal women with … Ended

2024-512997-89-00 Cancer 2019-01-29
Explore the safety and efficacy of subretinal administration of CPK850 gene therapy in patients with retinitis pigmentosa caused by mutation… Ended

2023-508688-54-00 Retinitis pigmentosa caused by biallelic mutations in t 2018-08-22
Study to test the safety and the initial efficacy of an investigational medicinal product, abbreviated as AAV9-hSGSH, in children with Sanfi… Ended

2024-515835-31-00 Mucopolysaccharidosis type IIIA (Sanfilippo A syndrome) 2018-03-20
Safety and pharmacokinetics of odm-208 in patients with metastatic castration-resistant prostate cancer Ended

2024-517439-39-00 Metastatic castration-resistant prostate cancer. 2018-03-19
Study of the safety, activity, and effect on the body of ASTX660 in people with advanced cancers. Ended

2024-516679-33-00 Advanced Solid Tumors and Lymphomas that are metastatic 2017-12-01
Safety and Efficacy of a Unilateral Subretinal Administration of HORA PDE6B in Patients with Retinitis Pigmentosa Harbouring Mutations in th… Ended

2024-511687-90-00 retinitis pigmentosa 2017-10-12
Phase I, Open-label, Dose-escalating, Clinical and Pharmacokinetic Study of PM14 Administered Intravenously to Patients with Advanced Solid … Ended

2024-511916-25-00 Advanced Solid Tumors 2017-09-04
A phase I/II, non randomized, monocentric open-label study of autologous CD34+ cells transduced with the G1XCGD lentiviral vector in patient… Ended

2024-512790-27-00 Treatment of X-linked Chronic Granulomatous Disease 2016-04-19