Phase I – First Administration to Humans

783 trials 323 recruiting

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A study to test the safety and efficacy of a new drug, AZD3470, in patients with advanced solid tumours. Recruiting

2023-506757-38-00 Advanced/metastatic solid tumors that are MTAP deficien 2024-11-14
A Clinical Trial to Assess a New Anti-Cancer Treatment (called DSB2455) Given On Its Own in Patients with Advanced Malignancies Recruiting

2023-508805-26-00 patients with active brain metastases, where the primar 2024-10-23
A Double-Blind, Randomized, Three-arm, Active-Controlled, Parallel-Group, Phase 1 Study Evaluating Pharmacokinetic Similarity of Three Formu… Recruiting

2023-510017-26-00 Completely Resected Stage IIB, IIC, and III Melanoma 2024-10-02
A Study to see how safe is RO7567132 as Single Agent and in Combination with Atezolizumab, how the body gets rid of it and how effective it … Recruiting

2024-512839-70-00 Advanced and/or Metastatic Solid Tumors 2024-08-27
A clinical study to assess if a new investigational medicinal product called JJP-1212 is safe, tolerable and able to induce a specific immun… Recruiting

2023-508661-33-00 Rheumatoid Arthritis 2024-05-29
A phase I, multicentre, open-label, dose escalation study to determine the safety and preliminary efficacy of MBS8(1V270) administered intra… Recruiting

2024-512294-26-00 Advanced solid tumors 2024-04-10
A phase 1 trial to study how safe and tolerable Lunresertib is, alone or in Combination with RP-3500 or Debio 0123, when administered in pat… Recruiting

2023-510063-35-00 Advanced solid tumors harboring either CCNE1 amplificat 2024-03-13
A Phase 1 Study of JNJ-87189401 Combined with JNJ-78278343 for Advanced Prostate Cancer Recruiting

2023-504063-17-00 Advanced Prostate Cancer 2024-03-08
A Phase 1 Study of JNJ-87801493 in Combination with CD3 T-Cell Engagers Recruiting

2023-505165-93-00 Non-Hodgkin Lymphoid Malignancies 2024-03-01
A First-in-Human Study of ABBV-525 (MALT1 Inhibitor) in B-Cell Malignancies Recruiting

2022-503136-13-00 various B-cell malignancies 2024-02-29
Study to evaluate the safety, tolerability, maximum tolerated dose and clinical activity of TNB-383B when given to patients with multiple my… Recruiting

2023-506993-11-00 Relapsed or refractory multiple myeloma 2023-11-23
A study to learn how safe the study treatment actinium-225-macropa-pelgifatamab (BAY3546828) is, how it affects the body, how it moves into,… Recruiting

2022-502623-22-00 Metastatic castration-resistant prostate cancer 2023-09-18
A Phase 1 first in human study evaluating safety, pharmacokinetics and efficacy of ABBV-400 as monotherapy and in combination with bevacizum… Recruiting

2023-509335-60-00 Advanced solid tumors including (but not limited to), n 2023-02-23
Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors Recruiting

2022-500508-23-00 Advanced solid tumors 2022-10-28
This is a first in human study, in patients with severe bleeding disorder (hemophilia A), who has developed inhibitory antibodies against co… Recruiting

2022-502030-12-01 Treatment of patients with Hemophilia A who have develo 2022-10-13
A Phase 1/2 Study of Bleximenib in Participants with Acute Leukemia Recruiting

2023-506581-31-00 Acute Leukemia 2021-06-15
Bioavailability, Biopotency and Food effect study of SCD0503 compared to subcutaneous regular human insulin Recruiting

2024-519502-12-00 Type 1 diabetes 2026-05-29
A clinical trial of MK-1824 in healthy participants (MK-1824-001) Recruiting

2026-525748-14-00 Heart failure with preserved ejection fraction 2026-05-26
A study to evaluate how well single and multiple doses of S072 are tolerated in healthy adult participants Recruiting

2025-525039-15-01 Pain 2026-05-25
SAR447971 first-in-human study Recruiting

2026-525333-22-00 Hidradenitis 2026-05-22
A study to assess the safety, and blood levels of CTX-187 after single and repeated intravenous doses in healthy volunteers and patients wit… Recruiting

2026-525619-15-00 Bacterial Infection 2026-05-22
A phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-DFC413 and s… Recruiting

2025-521702-18-00 Locally advanced unresectable or metastatic colorectal 2026-05-21
A Multicenter, Open-Label, Phase 1a/b First-in-Human Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitu… Recruiting

2025-524857-15-00 Advanced Solid Tumors 2026-05-19
A clinical trial of MK-4605 in healthy participants (MK-4605-001) Recruiting

2026-525627-24-00 Dementia 2026-05-13