Phase I – First Administration to Humans

783 trials 323 recruiting

Filter these 783 trials by condition, country, sponsor and more.

Open in Search →

A Phase I study to evaluate the safety and dosimetry of imaging with 68Ga-OncoACP3 in prostate cancer. Recruiting

2025-524594-16-00 Patients with prostate cancer with: - suspected metasta 2026-05-12
A study to test how different doses of BI 3814916 are tolerated by healthy people Recruiting

2025-523262-25-00 healthy volunteer trial 2026-05-11
A FIH study to investigate the safety and preliminary efficacy of expanded autologous urothelial cells bioprinted during orthotopic neobladd… Recruiting

2025-522963-14-00 Μuscle-invasive bladder cancer (MIBC) patients, eligibl 2026-05-09
A first in human study of the safety, pharmacokinetics and pharmacodynamics of KLR-003 in healthy participants and patients with immune medi… Recruiting

2026-525575-22-00 Psoriasis 2026-05-07
An Experimental Medicine multicenter Trial to evaluate the safety and immunogenicity of experimental versus authorized SARS-CoV-2 vaccine ca… Recruiting

2025-520652-28-00 healthy participants 2026-05-04
A research study investigating the effect of NNC0497-0040 in healthy participants, participants with overweight or obesity, and participants… Recruiting

2025-523978-16-00 Type I diabetes 2026-05-04
Dual-Wavelength Quantitative Fluorescence Endoscopy for Optical PD-1 and PD-L1 Imaging in Locally Advanced Esophageal Cancer: A Phase I Mult… Recruiting

2024-520090-12-00 Esophageal cancer 2026-05-01
A research study to evaluate the safety of NNC1679-0001 when given to healthy participants and participants with T2DM Recruiting

2025-523304-68-00 Healthy participants and participants with type 2 diabe 2026-04-30
A Phase 1 Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of BGB-B2033,… Recruiting

2025-524136-19-00 Selected Advanced or Metastatic Solid Tumors 2026-04-28
The clinical trial to study a new drug, AP-2. Recruiting

2025-524480-21-00 ALS and related disorders like frontotemporal dementia 2026-04-24
A Phase I Interventional Open-Label, Non-Randomized Dose-Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacody… Recruiting

2024-516660-28-01 Locally advanced, recurrent, or metastatic breast, gast 2026-04-17
A Phase 1a/1b Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Antitumor Activity of BG-75202, … Recruiting

2025-523553-34-00 Advanced and Metastatic Solid tumors 2026-04-15
A Study to Learn How Different Amounts of the Study Medicine Called PF-08065010 are Tolerated and Act in the Body of Healthy Adults Recruiting

2025-523759-76-01 Rheumatoid arthritis and Systemic Lupus Erythematosus 2026-04-15
A study in healthy men to test how well different doses of BI 3821001 are tolerated Recruiting

2025-523899-23-00 Healthy volunteer trial 2026-04-15
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-8520 in Subjects with Advanced KRA… Recruiting

2024-512515-45-01 Non-Small Cell Lung Cancer 2026-04-10
Trial to Evaluate the Safety and Preliminary Efficacy of GEN1079 in Participants with Advanced Solid Tumors Recruiting

2025-523931-21-00 Advanced Malignant Solid Tumors 2026-04-07
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of DNL628 in Participants with Early Alzheimer’s Diseas… Recruiting

2025-523515-11-00 Early Alzheimer's Disease 2026-04-03
Click-cleavable imaging in HER2-positive cancers (CleavHER trial). Recruiting

2025-520673-39-00 HER2-positive tumors 2026-04-02
PHASE 1 STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND IMMUNOGENICITY OF E-VIM VACCINE CVX1 WITH OR WITHOUT ICI IN THE TREATMENT OF SUBJECTS… Recruiting

2025-523781-25-00 metastatic solid cancer, muscle invasive bladder cancer 2026-04-02
Phase 1 Single Ascending and Multiple Ascending Dose Study with LCA-0321 Recruiting

2025-524053-14-00 Graves Disease 2026-04-02
Phase 1 open label trial of MST-0312 alone and in combination in subjects with solid malignancies Recruiting

2025-524446-10-00 Solid Malignancies 2026-04-01
A phase I study investigating the local tolerability and pharmacokinetics of isoniazid (INH) inhalation by wet nebulization in patients with… Recruiting

2024-517793-25-00 Tuberculosis 2026-03-30
A Study of PHN-012 in Patients With Advanced Solid Tumors Recruiting

2025-523756-31-00 Advanced Solid Tumors 2026-03-26
A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors Recruiting

2025-524334-26-01 Advanced or metastatic solid tumors 2026-03-26