Phase I – First Administration to Humans

783 trials 323 recruiting

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A Phase 1/1b First-in-Human Study of BMS-986506 in ccRCC Recruiting

2025-522543-18-00 Advanced Clear Cell Renal Cell Carcinoma 2026-03-25
ADCX-020 for the treatment of patients with locally advanced or metastatic cancers Recruiting

2025-523959-65-00 Locally Advanced or Metastatic Solid Tumors 2026-03-17
A study to see how RO7763505 works and how safe it is when given to healthy people and people with stable heart disease Recruiting

2025-524693-42-00 Stable Coronary Artery Disease (CAD) 2026-03-09
A Phase I study to evaluate the Safety, Tolerability, and Pharmacokinetics of BAL2420 in Healthy Adult Subjects Recruiting

2025-523108-59-00 Severe infections caused by Gram-negative bacteria 2026-03-04
Phase I, single and multiple ascending dose, randomized, double-blind, placebo-controlled, parallel-group clinical trial to evaluate the saf… Recruiting

2024-518758-18-02 Diabetic retinopathy. 2026-03-03
A study of the safety, tolerability, pharmacokinetics and preliminary efficacy of TNV108 in healthy adults and patients with diabetic periph… Recruiting

2025-524258-32-00 Diabetic Peripheral Neuropathy (DPN) 2026-03-02
Phase 1 First-in-Human Study of JNJ-95566692 in Participants with NHLs Recruiting

2025-523297-16-00 Non-Hodgkin Lymphoid Malignancies (NHLs) 2026-02-27
A Phase 1 first-in-human study to evaluate SAR447754 in healthy adult participants and in adult participants with moderate-to-severe atopic … Recruiting

2025-523826-41-00 Dermatitis atopic 2026-02-25
A trial to test the safety and tolerability of Lu AH70212 and Lu AH69593 in healthy adults. Recruiting

2025-522652-58-01 Narcolepsy 2026-02-19
A Phase 1 Study for ZW191 in Participants with Solid Tumors Recruiting

2024-512299-37-00 Advanced solid tumors 2026-02-18
A Phase 1, First-in-Human Study of MEN2312, a KAT6 inhibitor, as Monotherapy and in Combination in Participants with Advanced Breast Cancer Recruiting

2024-514661-19-01 Advanced ER+/HER2- Breast Cancer 2026-02-18
First-in-human (FIH) Trial of GEN3018 in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML) or Higher-risk Myelodysplastic Syndrome (… Recruiting

2025-523101-15-00 Relapsed or Refractory Acute Myeloid Leukemia or Higher 2026-02-16
A single and multiple ascending dose study of topical ladarixin ophthalmic solution in healthy volunteers Recruiting

2025-524527-46-00 Ocular inflammatory conditions 2026-02-16
Tolerance study of allogeneic of Adipose tissue derived mesenchymal Stroma/stem Cells (AdMSC) transplantation in patients with critical limb… Recruiting

2023-509312-29-00 critical limb ischemia 2026-02-11
Single and multiple ascending dose of ZP9830 in healthy participants Recruiting

2023-509929-51-00 Autoimmune diseases 2026-02-10
C5951001- A Phase 1 Study of PF-08046876 in Participants with Advanced Solid Tumors. Recruiting

2025-521729-33-00 advanced solid tumors 2026-02-10
A Phase 1a/1b, Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity … Recruiting

2025-523165-19-00 Advanced, metastatic or unresectable solid tumors 2026-02-10
A clinical trial investigating the safety and biological activity of the antibody BNT351 in adults living without and with HIV Recruiting

2025-523846-29-00 HIV-1 infection 2026-02-09
A study on the safety, tolerability, and effectiveness of the new drug LAD106 in healthy volunteers. Recruiting

2025-523328-31-00 Inflammatory diseases 2026-02-06
Phase 1 Single Ascending Doses (SAD) of M5542 in Healthy Participants Recruiting

2024-513069-37-00 Healthy 2026-01-30
Multiple Ascending Dose Study of LY4256984 in Participants with Sporadic Amyotrophic Lateral Sclerosis Recruiting

2025-521295-60-00 Sporadic Amyotrophic Lateral Sclerosis 2026-01-29
A Phase 1 Study for ZW251 in Participants with Solid Tumors. Recruiting

2025-523088-39-00 Advanced Solid Tumors 2026-01-28
FT819 in B-cell Mediated Autoimmune Diseases Recruiting

2024-517397-25-00 B-cell Mediated Autoimmune Diseases 2026-01-26
A multi-part, adaptive, Phase 1, first time in human study in healthy participants and participants with atopic dermatitis (AD) to assess th… Recruiting

2025-522216-17-00 Atopic Dermatitis 2026-01-26