Phase I – First Administration to Humans

783 trials 323 recruiting

Filter these 783 trials by condition, country, sponsor and more.

Open in Search →

A Phase I/IIa Clinical Trial to Assess the Safety, Tolerability, and Efficacy of a Single Intravitreal Injection of SPVN20 Gene Therapy in P… Recruiting

2025-520665-47-00 End-stage rod-cone dystrophy 2025-10-08
A Phase 1/1b Study of IAM1363 in HER2 Cancers Recruiting

2024-519188-17-00 Relapsed/refractory malignancy with documented diagnosi 2025-10-07
Long-term follow-up of patients treated with GD2IL18CART Recruiting

2025-521497-34-00 Neuroblastoma 2025-10-06
A study to test a new immunotherapy, ABX-001, alone and in combination with the marketed drug, pembrolizumab, for the treatment of tumors pr… Recruiting

2024-512403-39-01 Advanced Solid Tumors Who Are Beyond Standard of Care 2025-10-03
Dose Escalation and Dose Expansion Study of BBO-10203 in Subjects with Advanced Solid Tumors Recruiting

2024-519445-29-00 Solid Tumors 2025-10-02
HER2-Targeting Site-Specific Labelled 89Zr-Trastuzumab PET Imaging of Patients with Cancer Recruiting

2024-516786-37-00 Patients with breast cancer, gastroesophageal adenocarc 2025-09-22
A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Compared to Oral Lenvatinib Capsul… Recruiting

2024-518012-39-00 Squamous-Cell Non-Small Cell Lung Cancer 2025-09-22
A Study of NTX-1088 as Monotherapy and Combined with Pembrolizumab Recruiting

2024-520077-12-00 Patients with Advanced Solid Malignancies 2025-09-15
A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese and Japanese Participants, a… Recruiting

2024-514186-18-00 Systemic Lupus Erythematosus 2025-09-09
A study investigating the safety, tolerability, pharmacokinetics (absorption, distribution, metabolism and elimination) and effect of single… Recruiting

2025-522368-34-00 Alzheimer’s Disease 2025-09-05
PSEUDOVAX – A CANCER VACCINE TARGETING MUTATED GNAS COMBINED WITH IMMUNE CHECKPOINT INHIBITION FOR PATIENTS WITH PSEUDOMYXOMA PERITONEI Recruiting

2024-517047-30-01 Pseudomyxoma Peritonei 2025-09-01
A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic… Recruiting

2024-516772-15-00 Prostate Cancer 2025-08-29
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Tolerability, Pharmacokinetic, Pharmacodynamic, and Prelimina… Recruiting

2025-522126-13-00 Cold Induced Urticaria 2025-08-29
A Phase 1 Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants with Severe, Refractory Autoimmune Diseases Recruiting

2024-517681-41-00 Systemic Sclerosis 2025-08-29
A first-in-human study of KK8123 in adults with X-linked hypophosphatemia Recruiting

2023-509390-23-00 X-linked hypophosphatemia. 2025-08-29
A study to evaluate how well single and multiple doses of O3R-5671-PRO are tolerated in healthy adult subjects Recruiting

2025-522571-28-00 Inflammatory bowel diseases and psoriasis. 2025-08-28
A First-in-human Study to Evaluate the Safety and Anticancer Effect of Several Doses of TH9619 in Patients with Advanced Cancer (ODIN). Recruiting

2024-519639-40-00 Solid tumors (including Non-Small Cell Lung Cancer (NSC 2025-08-18
A clinical trial for patients with relapsed or refractory multiple myeloma, using an experimental drug called ISB 2001 for the first time in… Recruiting

2023-507071-21-01 Relapsed/Refractory Multiple Myeloma 2025-08-14
A study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of GSK4771261 in healthy participants and participants w… Recruiting

2024-516095-15-00 Kidney Disease 2025-08-05
A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma Recruiting

2024-519499-22-00 Advanced or Metastatic Hepatocellular Carcinoma 2025-08-04
First in human pilot study to assess the safety and efficacy of dendritic cells loaded with frameshift derived neopeptides for the preventio… Recruiting

2025-521109-42-00 Lynch Syndrome 2025-08-01
A Phase 1 Study of WVE-007 in Adults Living with Overweight or Obesity Recruiting

2024-520203-41-00 Adults Living with Overweight and Obesity 2025-07-25
A study to investigate the safety and efficacy of SAR446523 injected subcutaneously in adult participants with relapsed/refractory myeloma Recruiting

2024-511667-28-00 Plasma cell myeloma refractory 2025-07-21
Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of [177Lu]Lu-NNS309 in pati… Recruiting

2023-510356-23-00 Locally advanced or metastatic unresectable colorectal 2025-07-18