Phase I – First Administration to Humans

783 trials 323 recruiting

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A first-in-human (FIH) clinical trial to investigate the human monoclonal antibody NG004, administrated intrathecally in acute spinal cord i… Recruiting

2024-514303-34-00 Acute Incomplete Cervical Spinal Cord Injury 2024-12-18
A First-in-Human clinical trial assessing safety of ES2B-C001 with or without Montanide in patients with HER2 expressing metastatic breast c… Recruiting

2024-516333-12-00 HER2 positive patients under HER2 maintenance therapy ( 2024-12-16
A trial to learn if AZD5492 is safe and works alone and in combination with other cancer treatments in adults with B-cell blood cancers. Recruiting

2024-511099-34-00 B-Cell Malignancies 2024-12-12
Study of the compound RCS-21 on the safety of healthy volunteers, its tolerability and on the way the body absorbs, distributes, and gets ri… Recruiting

2024-512351-21-00 Safety, tolerability and pharmacokinetics of single-as 2024-12-10
CRISPR-TIL for metastatic melanoma Recruiting

2023-510417-25-01 Advanced or metastatic melanoma 2024-12-06
PET-imaging of two Vartumabs (F8scFv and C9scFv) in patients with solid tumors – a Phase 0 basket trial Recruiting

2024-513827-18-00 Multiple solid tumors including: colorectal carcinoma ( 2024-11-29
A Phase 1 Study of BMS-986453 in Participants with Relapsed and/or Refractory Multiple Myeloma Recruiting

2023-506003-26-00 Relapsed and/or Refractory Multiple Myeloma 2024-11-27
Evaluation of the Novel Therapeutic Hepatitis B Virus Synthetic Long Peptide Vaccination ISA104 (HEB-PEP) Recruiting

2024-518355-36-01 chronic Hepatitis B 2024-11-27
A Phase 1 Open-label Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAS-004, a MEK (1/2) Inhibitor, in … Recruiting

2024-510900-34-00 Solid Tumors 2024-11-22
A Study of ZL-1310 in Patients with Small Cell Lung Cancer to Find a Suitable Dose and to Test How Different Doses of ZL-1310 are Tolerated … Recruiting

2024-514446-36-00 Small Cell Lung Cancer 2024-11-21
Phase 1 study to evaluate [18F]ACI-19626 as a potential PET radioligand for imaging TDP-43 inclusions in the brain of patients with suspecte… Recruiting

2024-513097-21-00 Alzheimer's Disease 2024-11-20
A study to learn BAY 3498264 when given alone or together with sotorasib in participants who have advanced solid cancers with specific genet… Recruiting

2024-513300-34-00 Advanced solid tumors harboring KRAS G12C mutation 2024-11-18
NANOFER-THE-0504: A Trial to Assess the Safety and Tolerability of an Investigational Drug THE-0504 for Patients With Solid Tumors Recruiting

2023-503787-17-00 Solid tumors 2024-11-13
First-In-Human study evaluating the Safety of administration of ABD-3001 to Patients with Relapsed/Refractory Acute Myeloid Leukemia or Hig… Recruiting

2024-518813-24-00 Patients with Relapsed/Refractory Acute Myeloid Leukemi 2024-11-12
Phase 1 Study of IMC-P115C in Advanced PRAME Positive Cancers Recruiting

2023-509767-25-00 Advanced PRAME Positive Cancers 2024-11-07
RESTART; Autologous Transplantation of Adult Salivary Gland Stem Cells to Restore Submandibular Gland Function after Radiotherapy Recruiting

2024-512968-57-00 Patients operated with curative intend for head and nec 2024-11-01
A Study to Investigate the Safety and Efficacy of KQB198 as Monotherapy and in Combination in Participants with Advanced Solid Malignancies Recruiting

2024-511453-22-00 Participants with Advanced Solid Malignancies 2024-10-28
CAR123 T cell treatment of relapsed/refractory hematologic malignancies. Recruiting

2022-503165-30-00 Relapsed/refractory CD123+ hematological malignancies: 2024-10-23
Comparison between ABP 234 and Keytruda® (Pembrolizumab) Recruiting

2024-514304-14-00 Advanced or Metastatic Non-squamous Non-Small Cell Lung 2024-10-08
Double-blind, randomized, placebo-controlled, pilot clinical trial to evaluate the safety, tolerability and efficacy of two doses of a condi… Recruiting

2023-507700-32-00 Acute respiratory distress syndrome (ARDS) caused by SA 2024-10-02
A Study to Evaluate ARV-393 in Adult Participants with Advanced Non-Hodgkin’s Lymphoma Recruiting

2023-510136-36-00 Advanced Non-Hodgkin’s Lymphoma 2024-09-27
First-in-human Trial of EGL-001 in Patients with Selected Advanced and/or Metastatic Solid Tumors Recruiting

2024-512921-10-00 Advanced and/or Metastatic Solid Tumors 2024-09-27
A study to characterise the safety, tolerability and efficacy of LY4170156 in subjects with advanced solid tumors Recruiting

2024-511238-11-00 Ovarian cancer, endometrial cancer, cervical cancer, no 2024-09-20
A study to test how well different doses of BI 3804379 are tolerated by healthy people and patients with MASH Recruiting

2024-513549-36-01 Metabolic Dysfunction-associated Steatohepatitis 2024-09-10