Phase I – First Administration to Humans

783 trials 323 recruiting

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Randomized, double-blind, placebo-controlled Phase I study in healthy individuals on autotaxin-inhibition with MJK2134025 in single-ascendin… Recruiting

2024-513116-10-00 Stroke 2025-03-31
A Phase 1a/b Study Investigating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Preliminary Antitumor Activity of PRMT5 I… Recruiting

2024-515307-19-00 Advanced, or metastatic solid tumors with methylthioade 2025-03-24
Ph 1 Study of ORIC-944 in Patients with Metastatic Prostate Cancer. Recruiting

2024-515527-11-00 Prostate cancer 2025-03-20
KO-2806 Monotherapy and Combination Therapies in Advanced Solid Tumors Recruiting

2024-513285-19-00 Pancreatic Ductal Adeno Carcinoma 2025-03-14
A clinical study of MK-0472 in people with solid tumors (MK-0472-001) Recruiting

2024-516006-32-00 Malignant Neoplasm - Solid Tumors 2025-03-11
A Study of Orally Administered MOMA-313 in Participants with Advanced or Metastatic Solid Tumours Recruiting

2024-513502-62-00 Advanced or Metastatic Solid Tumors 2025-03-07
A Study to Evaluate ALN-HTT02 in Adult Patients with Huntington’s Disease Recruiting

2024-515732-68-00 Huntington’s disease 2025-03-07
MAESTRO-4MS : "Allogenic Adipose tissue-derived Mesenchymal Stromal Cells for the treatment of Primary Progressive Multiple Sclerosis: an op… Recruiting

2023-509538-20-01 Primary Progressive Multiple Sclerosis 2025-03-06
Phase 1 study to evaluate [18F]ACI-15916 as a potential PET radioligand for imaging α-synuclein deposits in the brain of patients with suspe… Recruiting

2024-515664-31-00 Parkinson's Disease 2025-03-04
Anti-GD2 ADC M3554 in Advanced Solid Tumors Recruiting

2024-513687-26-00 Advanced Solid Tumors 2025-02-25
Quantitative Fluorescence molecular imaging in Crohn’s disease and psoriasis Recruiting

2023-506192-10-00 Crohn's disease 2025-02-14
A Phase 1 Prospective, Open-label, First-in-human Study to Evaluate the Safety, Tolerability and Biodistribution of [177Lu]Lu-AKIR001 and it… Recruiting

2023-508126-95-00 The target population of the trial consists of patients 2025-02-10
A study to characterise the safety, tolerability and efficacy of LY3962673 in subjects with advanced solid tumors. Recruiting

2024-516440-25-00 KRAS G12D-mutant solid tumors. 2025-02-06
A Phase 1 Study of JNJ-89853413 for Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Neoplasms Recruiting

2024-513199-16-00 Relapsed or Refractory Acute Myeloid Leukemia or Relaps 2025-02-04
A placebo-controlled, single-blind, phase I study in healthy volunteers and patients with Rheumatoid Arthritis with ABO21009 Recruiting

2024-517547-31-00 Rheumatoid Arthritis 2025-01-31
Application of the autologous CAR T cells (Tarcidomgen Kimleucel) in the treatment of refractory and relapsed CD19+ B cell neoplasms Recruiting

2025-520653-37-00 Application of the autologous CAR T cells (Tarcidomgen 2025-01-30
Phase I / II clinical trial, randomized, exploratory and prospective to evaluate the safety and efficacy of the transfusion of autologous TR… Recruiting

2024-519845-30-00 To evaluate the efficacy in the prevention of the rejec 2025-01-30
PET imaging of CD8 T lymphocyte recruitment induced by radiotherapy locally and remotely Recruiting

2024-517640-57-01 Patients with polymetastatic solid cancers. 2025-01-24
Phase I, open-label clinical trial to evaluate the safety and clinical response of repeated-dose intra-arterial infusion of autologous mesen… Recruiting

2024-520427-86-00 Autoimmune refractory epilepsy and Rasmussen Encephalit 2025-01-24
A first-in-human study to determine the safety and tolerability of different doses of GEH200520 Injection and GEH200521 (18F) Injection and … Recruiting

2024-515218-42-00 Irresectable or metastatic solid tumour or a local and 2025-01-23
Phase 1 Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancer Recruiting

2024-516526-66-00 Metastatic colorectal cancer and Gastric cancer 2025-01-21
Single microdose trial - CXCR4 PET tracer - Pharmacokinetics and pharmacodynamics of [68Ga]Ga-R54, a CXCR4-targeted radiopharmaceutical in p… Recruiting

2024-513303-14-00 Advanced solid neoplasm (breast, lung, colon, ovary, pa 2025-01-08
A study in healthy men to test how well different doses of BI 3776528 are tolerated Recruiting

2024-515222-92-00 Healthy volunteer trial 2025-01-08
Phase 1, open-label, multicenter, dose escalation study of SRG-1505 as monotherapy in subjects with mature b-cell malignancies Recruiting

2023-505204-34-00 Mature B-Cell Neoplasm, Non-Hodgkin Lymphoma, Diffuse l 2024-12-30