Therapeutic Confirmatory (Phase III)

3,259 trials 1,319 recruiting

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Evaluation of the effects of bosentan in the management of patients in the acute phase of acute anterior ischemic optic neuropathy. Ended

2024-518345-21-00 early stage of acute non-arteritic anterior ischemic op 2015-07-31
Adjuvant immunotherapy with anti-PD-1 monoclonal antibody Pembrolizumab (MK-3475) versus placebo after complete resection of high-risk Stage… Ended

2023-509136-25-00 Stage III melanoma (AJCC R0) with histologically confir 2015-07-16
Phase III trial of laryngeal preservation comparating chemotherapy followed by radiotherapy to chemotherapy administrated during radiotherap… Ended

2024-513976-16-00 squamous cell carcinomas of the larynx or hypopharynx l 2015-06-26
A Randomized, Multicenter, Open-Label, 3 Arm Phase 3 Study of Obinutuzumab in Combination with Chlorambucil, ACP 196 in Combination with Obi… Ended

2023-509348-84-00 Chronic Lymphocytic Leukemia 2015-04-27
An Efficacy and Safety Study of JNJ56021927 in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC) Ended

2023-508606-26-00 Metastatic castration-resistant prostate cancer (mCRPC) 2015-04-23
An open-label extension study of pertuzumab administered on its own or in combination with other anti-cancer therapies in patients previousl… Ended

2023-505102-42-00 Solid Malignant Tumors 2014-12-18
Randomised phase 3 trial of enzalutamide in first line androgen deprivation therapy for metastatic prostate cancer: ENZAMET Ended

2024-516137-13-00 Metastatic Prostate Cancer 2014-12-18
Further 2 years of adjuvant imatinib may improve recurrence-free survival (RFS) of patients who are at a high risk of GIST recurrence despit… Ended

2024-512243-23-00 gastrointestinal stromal tumor 2014-11-07
A Study of Abemaciclib (LY2835219) in Participants With Previously Treated KRAS Mutated Lung Cancer (JUNIPER) Ended

2023-506779-82-00 Non Small Cell Lung Cancer 2014-11-04
A Study of abemaciclib Combined with Fulvestrant in Women With Hormone Receptor Positive HER2 Negative Breast Cancer Ended

2023-506781-30-00 Breast cancer 2014-09-17
A Phase III double-blind placebo-controlled Randomised Trial of Aspirin on Recurrence and Survival in Colon Cancer Patients Ended

2022-502324-48-00 Patients with resected colon carcinoma 2014-08-05
Olaparib as adjuvant treatment in patients with germline BRCA mutated high risk HER2negative primary breast cancer. Ended

2024-511096-15-00 Breast Cancer 2014-08-01
HOVON 127 BL / SAKK 37/16: Phase III study comparing 2 treatments (R-CODOX-M/R-IVAC versus DA-EPOCH-R) in patients with Burkitt lymphoma Ended

2023-503423-25-00 Burkitt lymphoma 2014-06-19
A randomized phase III multicenter trial assessing efficacy and toxicity of a combination of Rituximab and Lenalidomide (R2) vs Rituximab al… Ended

2024-511640-11-00 Follicular lymphoma 2014-05-15
A Clinical study to assess the safety and effectiveness of ARN-509 in men with Castration-Resistant Prostate Cancer (prostate cancer not res… Ended

2023-509221-47-00 Castration-Resistant Prostate Cancer 2014-02-12
A Controlled Study with an active treatment and a Placebo to Assess the Efficacy and Safety of Weekly Intravenous Product in Subjects with P… Ended

2023-510030-83-00 Pulmonary Emphysema due to Alpha-1-Antitrypsin Deficien 2014-01-29
A large-scale comparative study evaluating an intravenous treatment, cabazitaxel, and radiation therapy to the pelvic lymph nodes in patient… Ended

2024-517622-25-00 Patients with localized prostate cancer and high-risk f 2013-12-06
A Phase 3b, Multicenter, Open-label, PCI-32765 (Ibrutinib) Long-term Extension Study Ended

2023-503803-27-00 B-cell non-Hodgkin's lymphoma and cGVHD 2013-10-25
Neoadjuvant chemotherapy versus standard treatment in patients with locally advanced colon cancer (NeoCol) Ended

2024-514294-22-01 Colon cancer 2013-10-14
Olaparib Monotherapy in Patients with BRCA Mutated Ovarian Cancer following First Line Platinum Based Chemotherapy. Ended

2024-511142-39-00 BRCA Mutated Advanced (FIGO Stage III-IV) Ovarian Cance 2013-09-06
A two-year, double-blind, randomized, multicenter, active controlled Core Phase study to evaluate the safety and efficacy of fingolimod admi… Ended

2023-507556-68-00 Multiple Sclerosis 2013-07-26
Safety Study of Adding Everolimus to Adjuvant Hormone Therapy in Women With High Risk of Relapse, ER+ and HER2- Primary Breast Cancer, Free … Ended

2024-516198-61-00 Patients with high risk of relapse, ER+ and HER2- prima 2013-06-05
"A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone… Ended

2024-515368-29-00 patients with node positive breast cancer who do not ha 2012-09-20
SWOG S1007: A Phase III, Randomized Clinical Trial of Standard Adjuvant Endrocrine Therapy +/- Chemotheraphy in Patients with 1-3 Positive N… Ended

2024-516801-22-00 Patients with 1-3 positive Nodes, Hormone Receptor-Posi 2012-04-26