Nervous System Diseases

1,005 trials 421 recruiting

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A 12-Month Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS2) Ended

2023-506724-85-00 Migraine 5 2020-11-19
A Study of Lasmiditan (LY573144) Treatment in Children Aged 6 to 17 With Migraine (PIONEER-PEDS1) Ended

2023-506253-38-00 Migraine 5 2020-11-09
Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor tolebrutinib (SAR442168) (PERSEUS) Ended

2024-514495-41-00 Primary Progressive Multiple Sclerosis 5 2020-11-04
A Trial to Test if Fremanezumab is Effective in Preventing Migraine in Children and Adolescents Ended

2024-512837-34-00 Episodic and Chronic Migraine 5 2020-10-14
A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease Ended

2023-507303-55-00 Alzheimer Disease 4 2020-09-30
A study to assess how ALZ-801 affects laboratory tests and symptoms of Alzheimer's disease in patients who have a specific genotype (APOE4). Ended

2024-515858-25-00 Subjects with a clinical diagnosis of Alzheimer's disea 4 2020-09-30
Investigation the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7248824 in Participants with Angelman Syndrome Ended

2024-514797-45-00 Angelman Syndrome (AS) 3 2020-08-25
An open-label study evaluating ofatumumab treatment effectiveness and PROs in subjects with RMS transitioning from fumarate-based RMS approv… Ended

2023-507493-41-00 relapsing multiple sclerosis (RMS) 5 2020-08-04
Safety And Efficacy Study Of Intravenous (IV) Administration Of Elezanumab To Assess Change In Upper Extremity Motor Score (UEMS) In Adult P… Ended

2023-505125-14-00 Acute Traumatic Cervical Spinal Cord Injury 4 2020-07-24
A Phase 3 Study to Evaluate Efficacy and Safety of AL001 in Frontotemporal Dementia (INFRONT-3) Ended

2023-506873-36-00 Frontotemporal dementia (FTD) 5 2020-06-29
An extension study to learn about the long-term safety of fenfluramine hydrochloride for seizures in children and adults with rare seizure d… Ended

2024-515680-61-00 Dravet syndrome or Lennox-Gastaut syndrome 5 2020-02-07
The MiBlock study Ended

2024-515165-34-00 Chronic migraine 5 2019-10-01
A Single-arm Study of Intrathecal SHP611 in Subjects with Metachromatic Leukodystrophy Ended

2024-514402-31-00 Late Metachromatic Leukodystrophy (MLD) 4 2019-09-09
Evaluation of Safety, Tolerability, and Changes in Biomarker and Clinical Outcome Assessments of Losmapimod for FSHD1 With Extension (FSHD) Ended

2024-512736-29-00 Facioscapulohumeral Muscular Dystrophy 1 (FSHD1) 4 2019-08-23
Open-label Follow-up Study of Soticlestat in Adults and Children with Developmental Epileptic Encephalopathies Ended

2022-502801-13-00 Epileptic Encephalopathies: Dravet Syndrome, Lennox Gas 4 2019-07-26
Efficacy and Safety of Erenumab in Pediatric Subjects With Chronic Migraine Ended

2023-504928-26-00 Chronic Migraine 5 2019-07-19
Prospective, randomised, placebo-controlled study of polyvalent intravenous immunoglobulins for the treatment of primary Sjögren's syndrome … Ended

2024-517309-95-00 -Peripheral neuropathy clinically defined: *Pure sensit 5 2019-06-19
A Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Cenobamate Adjunctive Therapy in Su… Ended

2023-506687-13-00 Primary Generalized Tonic-Clonic Seizures 5 2019-01-31
A Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Multiple Sclerosis Previously Enrolled in A F. Hoffmann-la … Ended

2023-506543-41-00 Multiple sclerosis (MS) 5 2018-07-25
A study to investigate the safety, tolerability, and pharmacokinetics/pharmacodynamics of Risdiplam in adult and pediatric patients with spi… Ended

2023-506739-14-00 Spinal Muscular Atrophy (SMA) 4 2017-05-12
A Phase 2 Study of the Safety, Efficacy, and Pharmacodynamics of RTA 408 in the Treatment of Friedreich’s Ataxia Ended

2024-517436-22-00 Friedreich's ataxia 4 2016-07-21
Phase 3 Efficacy and Safety Study of BG00012 in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS). Ended

2023-505632-35-00 Relapsing-Remitting Multiple Sclerosis 5 2014-07-24
A safety and efficacy extension of study HGT-MLD-070 in Children with Metachromatic Leukodystrophy recieving enzyme (HGT-1110) replacement b… Ended

2024-514403-34-00 Late Metachromatic Leukodystrophy (MLD) 9 2012-10-10
A Study to Investigate Single Ascending Doses of Ocrelizumab for Safety and Side Effects, How The Body Handles It Over A Period of Time, How… Ended

2024-513639-26-00 Multiple Sclerosis (MS) 3