Nervous System Diseases

1,005 trials 421 recruiting

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Administration of a new gene therapy to patients affected by Hereditary Spastic Paraplegia Type 50 (SPG50) Pending

2025-522603-15-00 Hereditary Spastic Paraplegia Type 50 (SPG50) 4
A randomized, placebo-controlled trial to assess the efficacy, tolerability, and pharmacokinetics of clemastine in children and adults with … Pending

2025-524195-29-00 Pitt-Hopkins syndrome 4
IVIGSeN Pending

2022-501717-31-00 Idiopathic painful small fiber neuropathy or sensory ne 10
A double-blinded, randomized, placebo-controlled, multi-center trial of Efgartigimod in autoimmune dementia (EfgaDem) Pending

2023-510216-39-00 Autoimmune dementia 4
GRoningen Early-PD Ambroxol Treatment Pharmacokinetics Pending

2024-519088-16-01 Parkinson's disease 3
FIDES: Focused Ultrasound-mediated Blood-Brain Barrier Opening In Pontine Diffuse Midline Glioma (DMG) to Enhance Systemic Therapy with Temo… Pending

2025-520814-78-00 Diffuse Midline Glioma, H3K27-altered 9
Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL) Pending

2025-523389-26-00 Relapsed/refractory primary central nervous system lymp 5
Assessment of clozapine-related immunodeficiency effect in Parkinson's disease patients (CLOZIDPD) Pending

2024-514530-21-00 Parkinson's disease 6
A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis Recruiting

2025-523950-15-01 Generalized Myasthenia Gravis 4 2026-05-29
A Double-blind, Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults with Focal Seizures Recruiting

2025-524038-24-00 Focal Epilepsy 5 2026-05-22
An Open-label Study to evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Inebilizumab in children with gMG Recruiting

2025-520993-20-00 Generalized Myasthenia Gravis 4 2026-05-19
ACP-204 in Adults With Lewy Body Dementia Psychosis (LBDP) Recruiting

2025-521711-39-00 Lewy body Dementia psychosis (LBDP) 5 2026-05-17
Ublituximab in Pediatric Participants with Relapsing forms of Multiple Sclerosis (RMS) Recruiting

2025-522257-19-00 Relapsing Multiple Sclerosis 10 2026-05-12
Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS (PREVAiLS) Recruiting

2025-524002-16-00 Amyotrophic Lateral Sclerosis 5 2026-05-12
INTRATUMORAL DNX-2401 ADMINISTRATION FOR RECURRENT AND REFRACTORY HIGH GRADE BRAIN TUMORS IN PEDIATRIC AND YOUNG ADULT PATIENTS Recruiting

2024-515009-24-00 High grade malignant brain neoplasm 4 2026-05-08
A study to test the safety and disease progression following YTB323 (rapcabtagene autoleucel) administration in participant with progressive… Recruiting

2024-514006-31-00 Non-active Progressive Multiple Sclerosis (PMS) 9 2026-04-16
A Study to Investigate the Safety and Effects of LTX-002 Administered in the Spinal Canal of Participants with Amyotrophic Lateral Sclerosis Recruiting

2025-522039-33-00 Amyotrophic Lateral Sclerosis 7 2026-04-09
Prospective pilot study of L-dopa treatment in patients with a neurodevelopmental disorder linked to a pathogenic variant of the CTNNB1 gene Recruiting

2024-514852-34-01 Neurodevelopmental disorders 4 2026-04-08
Is adding Cilostazol to nimodipine improving neurological outcome of patients with Aneurysmal Subarachnoid Hemorrhage? A randomized, double … Recruiting

2024-516468-27-00 Aneurysmal Subarachnoid Hemorrhage 5 2026-04-07
A Phase IIb Study to Determine the Safety, Tolerability and Efficacy of a Daily Oral Dose of SCI-110 in Adult Patients with Tourette's Syndr… Recruiting

2024-512949-17-00 Tourette's syndrome in adults (≥18 and ≤65 years) in ou 4 2026-03-26
EMPEROR: A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen (STK-001) in Patients with Dravet Syndrome Recruiting

2024-519555-28-00 Dravet syndrome 5 2026-03-18
KHENERFIN Recruiting

2025-522361-30-00 Primary Mitochondrial Disease, Mitochondrial DNA 3243A> 5 2026-03-17
A study to assess the efficacy and safety of empasiprubart in adults with CIDP Recruiting

2025-520805-10-00 Chronic inflammatory demyelinating polyneuropathy (CIDP 5 2026-03-12
A study to learn if DM199 drug is safe and whether it works better than placebo for treating acute ischemic stroke Recruiting

2024-513911-28-00 Acute Ischemic Stroke 10 2026-03-04