Nutritional and Metabolic Diseases

441 trials 157 recruiting

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Phase2, double-blind, randomized, placebo-controlled, multicentre study to evaluation the safety, efficacy, and pharmacokinetics of TAK-242 … Not authorised

2022-501026-37-00 ACLF is a syndrome that occurs in patients with chronic 4
Short title: TOTT: Tailoring Obesity Treatment Trial Not authorised

2024-510802-10-00 Obesity (BMI ≧ 30kg/m2) 10
The Chronic kidney disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect (CAPTIVATE) Not authorised

2024-511325-67-00 Chronic kidney disease 5
Safety and efficacy of oral semaglutide in hyperglycaemic patients after renal transplantation Not authorised

2023-504159-29-00 Hyperglycaemia after renal transplantation 4
Senolytics to Improve Osteoporosis therapy: A randomised controlled clinical trial The SENIOR Trial Not authorised

2022-500669-28-00 Osteoporosis 4
Phase 1 study assessing the pharmacokinetics of NEX-22A in subjects with T2D Not authorised

2023-508054-25-00 Type 2 diabetes 3
ASPIRE-1: dApagliflozin SC0062 and Prevention of renal Injury; a Randomized Evaluation Not authorised

2023-504404-28-00 Chronic Kidney Disease 4
Insulin resistance in type 2 diabetes: evaluating the pathogenic mechanisms of insulin resistance in the myocardium and the effects of the t… Not authorised

2025-523374-17-01 Type 2 diabetes 6
A study to assess the long-term safety and clinical activity of mRNA-3927 in participants previously enrolled in the mRNA-3927-P101 study Pending

2022-502911-12-00 Propionic Acidemia 9
PODOMOUNT-Basket, a study to test whether BI 764198 helps adults and adolescents with different types of kidney disease Pending

2025-523425-17-00 Proteinuric kidney diseases 4
A Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Phase 1 Study of CMP-CPS-001 in Healthy Volunteers and Participants w… Pending

2025-520882-37-00 Urea cycle disorders (UCD) 1
Weight-loss Effects aNd absorption of Direct oral anticoagulants in roux-en-Y gastric bypass patients: a prospective study (WENDY) Pending

2024-519737-30-00 Roux-en-Y gastric bypass 6
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight With Weight-Related Comorbidities Who Do Not Have Diabetes Pending

2025-523486-17-00 Obesity 5
Efficacy and Safety of KAI-9531 in Participants Living With Obesity or Overweight and Diabetes Pending

2025-523510-87-00 Obesity 5
Efficacy and Safety of KAI-9531 compared with Semaglutide in Participants Living With Obesity Who Do Not Have Diabetes Pending

2025-523511-11-00 Obesity 5
Study of the faecal microbiota transfer in capsule form vs. placebo for the treatment of patients with non-alcoholic steatohepatitis Pending

2022-500185-94-01 non-alcoholic steatohepatitis 4
LOTUS Pending

2025-522111-42-02 muscle protein turnover hemodialysis 6
A research study to see how NNC0487-0111 affects the body’s energy use after a weight loss in adults living with obesity, compared to a low-… Pending

2025-522744-40-00 Obesity 3
MEDFAST-study Pending

2024-519774-40-00 People with a Body Mass Index (BMI) of 30 kg/m2 or more 6
The RJVA-001 First in Human Trial in Adults with Inadequately Controlled Type 2 Diabetes. Pending

2025-524438-24-00 Type 2 Diabetes 7
A study to investigate efficacy and safety with pegtibatinase compared to placebo in participants ≥12 to ≤65 years of age with classical hom… Pending

2023-504135-40-00 Classical Homocystinuria 5
Effect on the tolerability of semaglutide in overweight adults without diabetes Pending

2025-524612-11-00 Overweight and obesity 6
Assess effect and safety of intra-arterial autologous mesoangioblast administration to the upper arm of m.3243A>G mutation carriers Pending

2024-515129-27-00 m.3243A>G mutation causing mitochondrial myopathy 7
Effects and health economic aspects of enzyme therapy in children and adults with Pompe disease Pending

2024-518269-92-00 Pompe disease / glycogenosis type II / acid maltase def 6