Nutritional and Metabolic Diseases

441 trials 157 recruiting

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Phase 1/2 Study of ABO-101 in Primary Hyperoxaluria Type 1 Recruiting

2024-518144-20-00 Primary Hyperoxaluria Type 1 (PH1) 7 2025-09-03
A study to investigate the safety and efficacy of mRNA-3927 in participants with genetically confirmed propionic acidemia Recruiting

2022-502910-10-00 Propionic Acidemia 7 2025-08-11
Efficacy and safety trial of intraperitoneal furosemide in patients on peritoneal dialysis Recruiting

2024-519356-87-00 Dialysis Heart failure 6 2025-06-13
A trial to test whether ORE-001 (oral lidocaine) leads to increased food intake and improved health and wellbeing in elderly underweight peo… Recruiting

2024-516958-22-00 Underweight 4 2025-02-17
Effect of patiromer in children under 12 years of age with high blood potassium levels Recruiting

2023-505252-21-00 Hyperkalemia 4 2025-02-14
A study to test whether survodutide helps people living with obesity or overweight and with a confirmed or presumed liver disease called non… Recruiting

2023-505303-23-00 Obesity 5 2024-07-26
Study to evaluate the safety and efficacy of Cipaglucosidase Alfa and Miglustat in pediatric subjects with late-onset Pompe disease Recruiting

2022-502547-36-00 Late-onset Pompe disease 5 2024-03-21
Clinical study to investigate the Efficacy and Safety of Encaleret Compared to Standard of Care treatment in patients with Autosomal Dominan… Recruiting

2022-501398-38-00 Autosomal Dominant Hypocalcemia Type 1 (ADH1) 5 2023-09-02
Adipose Tissue Heterogeneity and Its Link to Type 2 Diabetes: A Randomized Open Intervention Study That Compares Empagliflozin, Pioglitazone… Recruiting

2024-513416-98-00 Diabetes type 2 4 2023-01-23
AN OPEN-LABEL STUDY TO EVALUATE THE SAFETY AND PHARMACOKINETICS OF MIGALASTAT HCL IN SUBJECTS WITH FABRY DISEASE AND AMENABLE GLA VARIANTS A… Recruiting

2022-500488-10-00 Fabry Disease and Amenable GLA Variants and Severe Rena 5 2022-12-19
Phase 1/2 dose-escalation study to evaluate the safety, tolerability, and efficacy of a single intravenous infusion of SPK-3006 in adults wi… Recruiting

2023-509303-32-00 Pompe Disease (also known as glycogen storage disease t 7 2021-10-19
Study for patients with Primary Hyperoxaluria and Severe Renal Impairment to evaluate the efficacy, safety and tolerability of DCR-PHXC. Recruiting

2024-512259-19-00 Primary Hyperoxaluria 4 2021-04-08
A Phase 3 Study of Etelcalcetide in Children With Secondary Hyperparathyroidism Receiving Hemodialysis Recruiting

2023-506471-10-00 Secondary hyperparathyroidism (SHPT) in pediatric patie 5 2019-10-04
Bioavailability, Biopotency and Food effect study of SCD0503 compared to subcutaneous regular human insulin Recruiting

2024-519502-12-00 Type 1 diabetes 1 2026-05-29
Multiple Dose Study of RO7795068 and its effect on Gastric Emptying, and on PK of Oral Contraceptives Recruiting

2025-524052-58-00 Healthy Overweight or Obese 3 2026-05-21
A Single-Dose Pharmacokinetic Study of Eloralintide in Participants with Varying Degrees of Liver Impairment and Participants with Normal Li… Recruiting

2025-523847-36-00 Participants with Mild, Moderate, or Severe Hepatic Imp 3 2026-05-19
AMAZE 2: A research study investigating how well the medicine NNC0487-0111 helps people with excess body weight and type 2 diabetes lose wei… Recruiting

2024-520441-23-00 Overweight or obesity, and type 2 diabetes 5 2026-05-13
EFFICACY AND SAFETY OF MET097 ONCE WEEKLY IN PEOPLE WITH OVERWEIGHT OR OBESITY AND TYPE 2 DIABETES (VESPER-5) Recruiting

2025-523975-48-00 Obesity 5 2026-05-08
AMAZE 1: A research study investigating how well the medicine NNC0487-0111 helps people with excess body weight lose weight Recruiting

2024-520440-42-00 Obesity 5 2026-05-07
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Dose-Finding Study of CX11 Tablets in Patients with Type 2 Diabetes Mellitus Recruiting

2025-524514-28-00 Type 2 Diabetes Mellitus 4 2026-05-06
AMAZE 4: A research study investigating how well the medicine NNC0487-0111 helps people with excess body weight and obstructive sleep apnoea… Recruiting

2024-520443-16-00 Overweight or obesity, and obstructive sleep apnoea tre 5 2026-05-04
A research study investigating the effect of NNC0497-0040 in healthy participants, participants with overweight or obesity, and participants… Recruiting

2025-523978-16-00 Type I diabetes 1 2026-05-04
AMAZE 3: A research study investigating how well the medicine NNC0487-0111 helps people with excess body weight and obstructive sleep apnoea… Recruiting

2024-520442-36-00 Overweight or obesity, and obstructive sleep apnoea not 5 2026-04-30
Evaluating the clinical effectiveness of sodium bicarbonate for critically ill patients with metabolic acidosis and acute kidney injury Recruiting

2025-523914-10-00 Critical illness 6 2026-04-30