Nutritional and Metabolic Diseases

441 trials 157 recruiting

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Pharmacokinetics, pharmacodynamics, safety, and tolerability of an acetonic milk thistle extract, standardized to silymarin, in subjects wit… Recruiting

2025-522423-95-00 chronic liver disease 3 2026-01-14
A phase 1 glucose clamp trial investigating the bioequivalence of CVC-001 cartridge vs U.S.-Licensed Lantus® in healthy male volunteers Recruiting

2024-516472-15-00 Type 1 diabetes mellitus (healthy participants) 2 2026-01-06
A study to investigate efficacy and safety of teplizumab compared with placebo in participants 1 to 25 years of age with Stage 3 Type 1 Diab… Recruiting

2024-519494-19-00 Nutritional and metabolic diseases 5 2025-12-22
The effect of colchicine, on insulin sensitivity in individuals with type 1 diabetes and systemic low-grade inflammation (INS1GHT) Recruiting

2025-522528-29-00 Type 1 diabetes 4 2025-12-22
Anti-inflammatory drug to prevent complications in type 1 diabetes Recruiting

2025-521397-34-00 Type 1 Diabetes 11 2025-12-15
Sonlicromanol in post-COVID: A randomized, double-blind, placebo-controlled, phase II trial Recruiting

2025-521866-92-01 long COVID 4 2025-12-12
A Clinical Trial of Tirzepatide (LY3298176) in Subjects With Overweight or Obesity and PCOS-related Ovarian Dysfunction (PERIODS) Recruiting

2024-515982-32-00 Overweight or Obesity 6 2025-12-09
A randomised, open-label, parallel group study to compare the pharmacokinetics and pharmacodynamics of NEODIDRO® 0.266 mg vs DIBASE® 25,000 … Recruiting

2024-516252-17-00 Patients with low Vitamin D plasma level 3 2025-12-09
Study to Evaluate Plozasiran in Adults with Hypertriglyceridemia (SHASTA-10 Study) Recruiting

2024-519712-13-00 Hypertriglyceridemia (HTG) 5 2025-12-08
A study to find out how EMPAgliflozin is tolerated and if it helps children and adolescents with chronic KIDNEY disease (EMPA-KIDNEY Kids) Recruiting

2024-512577-27-00 Chronic kidney disease in paediatric patients 5 2025-12-02
SGLT-2i, Heart, Improvement of Cardiovascular Autonomic Neuropathy Recruiting

2025-521748-39-00 type 2 diabetes 6 2025-11-14
Impact of Glucagon on Physical Capacity and Metabolism Recruiting

2025-521835-35-00 Heart Failure with preserved Ejection Fraction (HFpEF) 4 2025-11-14
A research study of a new medicine, NNC9733-0001, in healthy participants and participants with type 2 diabetes Recruiting

2024-519382-22-00 Healthy Participants and Participants with type 2 diabe 1 2025-11-10
Study to Evaluate Plozasiran in Adults with Severe Hypertriglyceridemia at high risk of Acute Pancreatitis (SHASTA-5 Study) Recruiting

2024-518206-40-00 Severe hypertriglyceridemia (SHTG) 5 2025-11-03
A PHASE 1 TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PK, AND PD of AX-0810 IN HEALTHY PARTICIPANTS Recruiting

2025-521876-77-00 Cholestatic liver disease 1 2025-11-03
Sotagliflozin for the treatment of post-bariatric hypoglycaemia: The ONSIDE study Recruiting

2023-509118-12-00 Postbariatric hypoglycaemia 4 2025-11-03
A phase 1, Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt (EYP651) and Evaluation of Potential Drug-Drug Interactions. Recruiting

2025-522915-40-00 Healthy volunteers, Impaired renal function and suspect 3 2025-10-28
Fluid administration in ketoacidosis Recruiting

2024-511513-37-00 Diabetic keto-acidosis 6 2025-10-23
PDH-RAVICTI - A PHASE II, MULTICENTRIC, PROSPECTIVE, NON-COMPARATIVE CLINICAL TRIAL TO ASSESS THE EFFICACY AND SAFETY OF THE TREATMENT OF PY… Recruiting

2024-516410-38-00 Pyruvate dehydrogenase deficiency 4 2025-10-01
Effect of levothyroxine and hypocaloric diet for the treatment of obesity. Recruiting

2024-514377-22-00 Metabolic disease 5 2025-09-04
A first-in-human study of KK8123 in adults with X-linked hypophosphatemia Recruiting

2023-509390-23-00 X-linked hypophosphatemia. 1 2025-08-29
A 26-week Study Comparing the Efficacy and Safety of Once-weekly Insulin Icodec and Once-daily Insulin Glargine U100, Both in Combination wi… Recruiting

2024-519945-31-00 Type 1 Diabetes 5 2025-08-21
A Study of LY3457263 Compared to Placebo in Participants with Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide Recruiting

2024-520328-27-00 Type 2 Diabetes 4 2025-08-07
Impact of Patiromer treatment on dietary Potassium intake restriction and health-related quality of life and nutrition in patients on Chroni… Recruiting

2025-521378-33-00 End Stage Kidney Disease on chronic dialysis therapy 5 2025-07-31