A randomised, open-label, reference-replicated crossover trial to investigate the bioequivalence of two formulations of Silexan 80 mg in healthy volunteers

2023-503647-34-00 Protocol D.01.01.2.03 Human pharmacology (Phase I) - Bioequivalence study Ended

Start 31 Aug 2023 · End 24 Jan 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol D.01.01.2.03

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Bioequivalence study
Status Ended
Participants planned 92
Countries 1
Sites 1

Healthy volunteers

Key facts

Sponsor
Dr. Willmar Schwabe GmbH & Co. KG
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
31 Aug 2023 → 24 Jan 2024
Decision date (initial)
2023-08-02
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Dr. Willmar Schwabe GmbH & Co. KG

Sponsor organisation
Dr. Willmar Schwabe GmbH & Co. KG
Address
Willmar-Schwabe-Strasse 4, Durlach Durlach
City
Karlsruhe
Postcode
76227
Country
Germany

Scientific contact point

Organisation
Dr. Willmar Schwabe GmbH & Co. KG
Contact name
Susanne

Public contact point

Organisation
Dr. Willmar Schwabe GmbH & Co. KG
Contact name
Susanne

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ended 92 1
Rest of world 0

Investigational sites

France

1 site · Ended
Biotrial
Unité Clinique, 7 Rue Jean Louis Bertrand, 35000, Rennes

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2023-08-31 2024-01-24 2023-09-06 2024-01-11

Application history

3 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-04-17 France Acceptable
2023-07-28
2023-08-02
2 NON SUBSTANTIAL MODIFICATION NSM-1 2023-09-27 France Acceptable
2023-07-28
2023-09-27
3 NON SUBSTANTIAL MODIFICATION NSM-2 2023-11-09 France Acceptable
2023-07-28
2023-11-09