A Phase 1, Randomized, Double-Blind, Placebo and Positive-Controlled Crossover Study to Evaluate the Effect of Clinical and Supraclinical Doses of GEH200486 0.5 M Injection on the Thorough QT/QTc in Healthy Volunteers.

2023-504310-30-00 Protocol GE-227-002 Human pharmacology (Phase I) - Other Ended

Start 16 Aug 2023 · End 25 Mar 2025 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol GE-227-002

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 72
Countries 1
Sites 1

Healthy volunteers

Key facts

Sponsor
GE Healthcare Limited
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Diagnosis [E01]
Trial duration
16 Aug 2023 → 25 Mar 2025
Decision date (initial)
2023-07-31
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteers

VersionLevelCodeTermSystem organ class
20.0 LLT 10019276 Heart disease unspecified 10007541

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

GE Healthcare Limited

Sponsor organisation
GE Healthcare Limited
Address
Pollards Wood, Nightingales Lane Nightingales Lane
City
Chalfont St. Giles
Postcode
HP8 4SP
Country
United Kingdom

Scientific contact point

Organisation
GE Healthcare Limited
Contact name
Jing Hao

Public contact point

Organisation
GE Healthcare Limited
Contact name
GE Healthcare

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ended 72 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ended
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2023-08-16 2025-03-25 2023-08-16 2024-03-11

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-06-19 Netherlands Acceptable
2023-07-31
2023-07-31
2 SUBSTANTIAL MODIFICATION SM-1 2023-12-20 Netherlands Acceptable
2024-02-05
2024-02-05
3 SUBSTANTIAL MODIFICATION SM-2 2024-02-14 Netherlands Acceptable
2024-02-27
2024-02-27
4 NON SUBSTANTIAL MODIFICATION NSM-1 2024-09-03 Netherlands Acceptable
2024-02-27
2024-09-03
5 SUBSTANTIAL MODIFICATION SM-3 2024-11-28 Netherlands Acceptable 2024-12-12