Nebulized fentanyl in healthy volunteers: comparison of facial versus intranasal aerosol administration by pharmacometric modeling. Pilot study AEROfen

2023-506016-40-00 Protocol 2022/0271/HP Human pharmacology (Phase I) - Other Ongoing, recruiting

Start 19 Apr 2024 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol 2022/0271/HP

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ongoing, recruiting
Participants planned 20
Countries 1
Sites 1

Healthy Volunteers

Key facts

Sponsor
CHU De Rouen
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Analytical, Diagnostic and Therapeutic Techniques and Equipment [E] - Anesthesia and Analgesia [E03]
Trial duration
19 Apr 2024 → ongoing
Decision date (initial)
2023-10-16
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy Volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

CHU De Rouen

3 Total trials 2 Recruiting
Academic / Non-commercial
Sponsor organisation
CHU De Rouen
Address
1 Rue De Germont, Bp 96031 Bp 96031
City
Rouen Cedex
Postcode
76031
Country
France

Scientific contact point

Organisation
CHU De Rouen
Contact name
Florian VALLIN

Public contact point

Organisation
CHU De Rouen
Contact name
Florian VALLIN

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
France Ongoing, recruiting 20 1
Rest of world 0

Investigational sites

France

1 site · Ongoing, recruiting
CHU De Rouen
Pharmacologie clinique, 1 Rue De Germont, Bp 96031, Rouen Cedex

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
France 2024-04-19 2024-04-26

Application history

5 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-06-30 France Acceptable
2023-10-05
2023-10-16
2 SUBSTANTIAL MODIFICATION SM-1 2023-11-29 France Acceptable
2024-02-12
2024-02-19
3 SUBSTANTIAL MODIFICATION SM-2 2025-09-03 France Acceptable
2025-10-08
2025-11-13
4 NON SUBSTANTIAL MODIFICATION NSM-1 2025-11-25 France Acceptable
2025-10-08
2025-11-25
5 NON SUBSTANTIAL MODIFICATION NSM-2 2026-02-11 France Acceptable
2025-10-08
2026-02-11