Randomized, open-label, single dose, three-period, three treatment cross-over bioavailability study comparing test products Rosuvastatin/Ezetimibe, tablets, 20 mg /10 mg or Ezehron Duo, 20 mg + 10 mg, tablet, both administered in combination with Nilemdo 180 mg film-coated tablets to reference products Nustendi 180 mg/10 mg film-coated tablets in combination with Crestor, 20 mg, film-coated tablets in healthy male and female subjects under fasting conditions.

2023-507048-35-00 Protocol 950/23 Human pharmacology (Phase I) - Other Ended

Start 11 Oct 2023 · End 4 Jan 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol 950/23

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 24
Countries 1
Sites 1

not applicable (submitted trial is bioavailability study in healthy subjects)

Key facts

Sponsor
Adamed Pharma S.A.
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Diseases [C] - Cardiovascular Diseases [C14]
Trial duration
11 Oct 2023 → 4 Jan 2024
Decision date (initial)
2023-10-02
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

not applicable (submitted trial is bioavailability study in healthy subjects)

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Adamed Pharma S.A.

Sponsor organisation
Adamed Pharma S.A.
Address
Ul. Mariana Adamkiewicza 6a, Pienkow Pienkow
City
Czosnow
Postcode
05-152
Country
Poland

Scientific contact point

Organisation
Adamed Pharma S.A.
Contact name
Pharmacokinetic Study Team

Public contact point

Organisation
Adamed Pharma S.A.
Contact name
Pharmacokinetic Study Team

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Czechia Ended 24 1
Rest of world 0

Investigational sites

Czechia

1 site · Ended
Quinta-Analytica s.r.o.
Clinical Unit, Prazska 1486/18c Hostivar, 102 00, Prague

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Czechia 2023-10-11 2024-01-04 2023-10-11 2023-10-21

Application history

2 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-08-03 Czechia Acceptable
2023-09-15
2023-10-02
2 NON SUBSTANTIAL MODIFICATION NSM-1 2023-10-10 Acceptable
2023-09-15