A trial to learn how much [11C]savolitinib enters the brains of healthy participants

2023-508334-34-00 Protocol D5084C00016 Human pharmacology (Phase I) - Other Ended

Start 27 Mar 2024 · End 24 Jun 2024 · Status Ended · 1 EU/EEA countries · 1 sites · Protocol D5084C00016

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Ended
Participants planned 8
Countries 1
Sites 1

Healthy Volunteers

Key facts

Sponsor
AstraZeneca AB
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Neoplasms [C04]
Trial duration
27 Mar 2024 → 24 Jun 2024
Decision date (initial)
2024-03-21
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy Volunteers

VersionLevelCodeTermSystem organ class
21.0 LLT 10053349 Pharmacokinetic study 10022891
21.1 PT 10036220 Positron emission tomogram 100000004848

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

AstraZeneca AB

Sponsor organisation
AstraZeneca AB
Address
Astraallen Gartuna, Karlebyhus Byggnad 674 Karlebyhus Byggnad 674
City
Sodertalje
Postcode
151 85
Country
Sweden

Scientific contact point

Organisation
AstraZeneca AB
Contact name
Clinical Study Information Center

Public contact point

Organisation
AstraZeneca AB
Contact name
Clinical Study Information Center

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Sweden Ended 8 1
Rest of world 0

Investigational sites

Sweden

1 site · Ended
Karolinska Institutet
Brain Molecular Imaging Center, Nobels Vag 6, 171 65, Solna

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Sweden 2024-03-27 2024-06-24

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2023-12-18 Sweden Acceptable
2024-03-19
2024-03-21