A Phase 1, Double-blind, Randomized, Three-arm, Parallel Group Study to Compare the Pharmacokinetics and Safety of a Single Subcutaneous Dose of PBP1502, EU-Humira®, and US-Humira® in Healthy Male and Female Subjects

2024-519145-30-00 Protocol SOLOMON-I Human pharmacology (Phase I) - Other Temporarily halted

Start 31 Mar 2022 · Status Temporarily halted · 1 EU/EEA countries · 1 sites · Protocol SOLOMON-I

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - Other
Status Temporarily halted
Participants planned 324
Countries 1
Sites 1

Healthy volunteers

Key facts

Sponsor
Prestige Biopharma Ltd
Participant type
Healthy volunteers
Age range
18-64 years
Gender
Male and Female
Therapeutic area
Not possible to specify
Trial duration
31 Mar 2022 → ongoing
Decision date (initial)
2024-10-31
Transition trial
Yes
Low-intervention
No
Rare-disease indication
No
Vulnerable population
No

External identifiers

EU CT number
2024-519145-30-00
EudraCT number
2021-003507-17
ClinicalTrials.gov
NCT05108259

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

Prestige Biopharma Ltd

Sponsor organisation
Prestige Biopharma Ltd
Address
21 Biopolis Road, #04-24 28 Nucleos South Building Biopolis #04-24 28 Nucleos South Building Biopolis
City
Singapore
Postcode
138567
Country
Singapore

Scientific contact point

Organisation
Prestige Biopharma Ltd
Contact name
SOLOMON-I Clinical Trial Team

Public contact point

Organisation
Prestige Biopharma Ltd
Contact name
SOLOMON-I Clinical Trial Team

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Spain Temporarily halted 93 1
Rest of world
Australia
231

Investigational sites

Spain

1 site · Temporarily halted
Universidad Autonoma De Madrid
Pharmacology, Calle Del Arzobispo Morcillo 4, 28029, Madrid

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Spain 2022-03-31 2022-03-31 2024-11-04

Oversight and notifications

Regulatory notifications under CTR Articles 38, 52, 53, 54 and 77

Temporary halts 1 · Art. 38 CTR

Temporary halt TH-55317

Halt date
2024-11-04
Member states concerned
Spain
Publication date
2024-11-04
Reason
Sponsor decision
Explanation
Due to business decisions that do not impact subject safety or benefit-risk balance.
Follow-up measures
No follow-up measures required as there are no active subjects and no impact to benefit-risk balance is expected.
Benefit-risk balance changed
No
Treatment stopped
Yes

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2024-10-24 Spain Acceptable
2024-10-31
2024-10-31