A Single-Center, Double-Blind, Randomized, Placebo Controlled Phase 1 Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single- and Multiple-Ascending Doses of ACI-19764 in Healthy Participants

2025-523885-25-00 Protocol ACI-19764-2501 Human pharmacology (Phase I) - First administration to humans Ongoing, recruiting

Start 21 Jan 2026 · Status Ongoing, recruiting · 1 EU/EEA countries · 1 sites · Protocol ACI-19764-2501

Overview

Sponsor-declared trial summary

Phase Human pharmacology (Phase I) - First administration to humans
Status Ongoing, recruiting
Participants planned 78
Countries 1
Sites 1

Healthy Volunteers

Key facts

Sponsor
AC Immune S.A.
Participant type
Healthy volunteers
Age range
18-64 years, 65+ years
Gender
Male and Female
Therapeutic area
Diseases [C] - Nervous System Diseases [C10]
Trial duration
21 Jan 2026 → ongoing
Decision date (initial)
2026-01-13
Transition trial
No
Low-intervention
No
Rare-disease indication
No
Vulnerable population
Yes

Trial design

CTIS Part I — objectives, methods, condition coding

Conditions and MedDRA coding

Healthy Volunteers

Sponsors and contacts

Sponsor organisations, regulatory contacts, third parties

AC Immune S.A.

Sponsor organisation
AC Immune S.A.
Address
Batiment B Epfl Innovation Park
City
Lausanne
Postcode
1015
Country
Switzerland

Scientific contact point

Organisation
AC Immune S.A.
Contact name
Clinical Trial Information

Public contact point

Organisation
AC Immune S.A.
Contact name
Clinical Trial Information

Locations

1 EU/EEA country · 1 investigational sites

By country

CountryMS statusPlanned subjectsSites
Netherlands Ongoing, recruiting 78 1
Rest of world 0

Investigational sites

Netherlands

1 site · Ongoing, recruiting
Pharmaceutical Research Associates Group B.V.
Program Management, Van Swietenlaan 6, 9728 NZ, Groningen

Country notifications

Trial-start, recruitment-start, end and early-termination notifications submitted per Member State

Country Trial startTrial end Recruitment startRecruitment end Early termination
Netherlands 2026-01-21 2026-01-28

Application history

1 submissions — initial application plus substantial / non-substantial modifications

#TypeCodeSubmittedReference MSConclusionDecision date
1 INITIAL IN 2025-11-17 Netherlands Acceptable
2026-01-13
2026-01-13