Phase I – First Administration to Humans

783 trials 323 recruiting

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Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ION464 Administered to Adults With Multiple System Atrophy (HORIZON) Recruiting

2024-512528-13-00 Multiple System Atrophy 2020-05-27
Combination of ALpelisib and Trametinib in progressive REfractory Meningiomas Recruiting

2024-515836-61-00 Menangiomas 2019-09-30
Mevrometostat Treatment Of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma Recruiting

2023-509179-18-00 Castration Resistant Prostate Cancer (CRPC) 2019-08-13
Pharmacokinetics of antibiotics in cerebrospinal fluid of children with malignant brain tumors – a pilot study Recruiting

2024-518808-43-00 brain tumors 2018-10-22
A pilot study to assess the impact of ABCB1 on the neuropharmacokinetics of the weak ABCB1 substrate [11C]metoclopramide Recruiting

2024-517875-19-00 Investigation in healthy volunteers and dementia patien 2017-10-12
A pilot study to assess the influence of drug transporters on brain and organ distribution of erlotinib in humans Recruiting

2024-516550-21-00 cancer 2015-06-26
A Phase 1 study to test for safety and activity of an oral investigational drug, in patients with AML or other blood or bone marrow malignac… Recruiting

2024-511344-11-00 AG-120 is being investigated for the treatment of patie 2014-07-18
A study to investigate the safety and tolerability of SDL-M1 nanoparticles in healthy volunteers Ended

2024-518889-27-00 Septic cholestasis 2026-04-02
A clinical study to investigate the safety, tolerability and pharmacokinetic profile of single ascending concentrations of OPT101 in periton… Ended

2025-522966-61-00 Chronic kidney disease 2026-02-16
Pharmacokinetic, Safety, Tolerability, and Immunogenicity Comparison of CKD-704 (risankizumab biosimilar), with EU-approved Skyrizi®, and US… Ended

2025-522345-21-00 Active psoriatic arthritis 2025-11-11
A study investigating the safety, absorption, and elimination of NT 0150, a new compound that may potentially be used in the treatment of br… Ended

2024-520142-32-00 Cryopyrin associated periodic syndrome 2025-09-08
A study to evaluate the safety and tolerability of JNJ-90106848 and to investigate how long JNJ-90106848 stays in and acts on the body (phar… Ended

2025-521004-21-00 Inflammatory Conditions 2025-08-21
A Study to Learn How Different Amounts of the Study Medicine Called PF-07985631 are Tolerated and Act in the Body in Healthy Adults Ended

2024-519215-33-00 IgA nephropathy 2025-08-07
TherVacB_Phase1a: Open phase 1a trial to assess the safety and immunogenicity of a heterologous protein prime/MVA boost therapeutic hepatiti… Ended

2024-514231-26-00 Chronic Hepatitis B 2025-07-08
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moder… Ended

2025-520503-27-00 Asthma 2025-07-01
An open-label safety and tolerability clinical trial of PST-611 in dry age-related macular degeneration. Ended

2024-519025-37-00 Dry age-related macular degeneration. 2025-06-19
A phase 1/2a multicenter trial to evaluate the safety and immunogenicity of the CD40.Pan.CoV vaccine, adjuvanted or not, as a booster in adu… Ended

2024-516767-92-01 Health Participants 2025-06-17
A Study to Learn How Different Amounts of the Study Medicine Called PF-07999415 are Tolerated and Act in the Body in Healthy Adults Ended

2024-520380-13-00 CCI 2025-06-17
A study to test different doses of BI 1831169 alone and in combination with an anti-PD-1 antibody in people with different types of advanced… Ended

2024-512504-19-00 solid tumors 2025-05-28
A study of the PAN-KRAS inhibitor LY4066434 in participants with KRAS mutant solid tumors. Ended

2024-516733-12-00 Pancreatic Ductal Adenocarcinoma, Non-small Cell Lung C 2025-05-13
A study to assess the safety and immunogenicity of a therapeutic hepatitis B virus vaccine, in healthy adults (RUBY). Ended

2025-521169-28-00 Hepatitis B 2025-05-06
A study for GSK3862995B in healthy participants and participants with Chronic Obstructive Pulmonary Disease Ended

2023-506880-32-01 Pulmonary Disease, Chronic Obstructive 2025-04-14
Phase 1 Safety and Tolerability Study of ALN-F1202 in Healthy Adults. Ended

2024-515286-34-00 Healthy Volunteer 2025-03-06
Phase I study to evaluate safety and immunogenicity of V-212 in healthy adult volunteers. Ended

2024-516008-41-00 Healthy Volunteers 2025-01-29