Nervous System Diseases

1,005 trials 421 recruiting

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A study to investigate the mass balance, absolute bioavailability (BA), pharmacokinetics (PK), and metabolism of a single oral dose 60 mg [1… Ended

2023-506044-16-00 There is no medical condition being investigated. 3 2023-12-14
A Phase 2 study (NEPTUNE-17) to evaluate efficacy and safety of GSK3858279 in DPNP. Ended

2022-502313-28-00 Diabetic Peripheral Neuropathic Pain 4 2023-12-14
A study to investigate the pharmacokinetics of remibrutinib in CSF in healthy participants. Ended

2023-506760-13-00 Healthy 3 2023-12-11
BRIGHT - A Phase II, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Multiple Doses of LT3001 Drug… Ended

2022-502001-15-00 Acute Ischemic Stroke (AIS) 4 2023-12-05
This is a clinical trial (study), to be conducted in several clinical sites worldwide, of an oral study drug which will be investigated in a… Ended

2023-503957-36-00 Moderate-to-Severe pruritus in adult subjects with nota 10 2023-12-04
CHemical OptImization of Cerebral Embolectomy in patients with acute stroke treated with mechanical thrombectomy 2 (CHOICE2TRIAL) Ended

2023-504262-32-01 Cerebral Embolectomy in patients with acute stroke 5 2023-11-16
A Multiple-Ascending-Dose Study of MK-4318 in Healthy Participants Ended

2023-507512-12-00 Pain 3 2023-11-16
A Phase 2 Safety, Tolerability, and Proof-of-Concept Study of VGL101 in Patients With Adult-Onset Leukoencephalopathy With Axonal Spheroids … Ended

2022-502505-15-00 Leukoencephalopathy 10 2023-11-09
A double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety, and tolerability of intravenous ganaxolone added to s… Ended

2022-502540-12-00 Refractory Status Epilepticus (RSE) 5 2023-11-09
A First in Human Study of IBC-Ab002 in Persons With Early Alzheimer's Disease (AD) Ended

2024-511770-76-00 Alzheimer's disease 1 2023-10-31
A randomized, double-blind, double dummy, placebo-controlled, four-way cross-over study to investigate the analgesic effects and CNS effects… Ended

2023-505793-15-00 Chronic pain 3 2023-10-30
Single Rising Dose Study of MK-1708 in Healthy Participants Ended

2023-506946-21-00 Amyotrophic lateral sclerosis and Alzheimer’s disease 1 2023-10-24
Open label, single-center, four-part registration pharmacokinetic study: Part I: Pilot 2-way cross-over randomized, comparative pharmacokine… Ended

2023-507316-12-00 Narcolepsy with cataplexy 3 2023-10-20
A clinical trial to investigate efficacy and safety of NT 201 injections compared with placebo injections in participants aged 18 years and … Ended

2022-501461-52-00 Moderate to severe chronic peripheral neuropathic pain 4 2023-10-17
Pharmacokinetic Study of Single and Multiple Dose of PKL-021 Administered Orally to Healthy Subjects Ended

2023-506633-30-00 N/A submitted trial is conducted on healthy subjects 3 2023-10-13
An Exploratory, Multicenter, Randomized, double-blind, placebo-controlled study evaluating the effect and safety of pitolisant in children a… Ended

2023-503678-18-00 Autism spectrum disorders 4 2023-10-10
PLAQUE AND BRAIN INFLAMMATION IN SYMPTOMATIC CAROTID STENOSIS: ROLE OF THE FICOLIN-2 STATEMENT Ended

2023-504573-20-00 stroke or transient ischemic attack 4 2023-10-09
A Study to Learn About the Safety of BIIB091 and Its Effect on Brain Inflammation When Taken Alone or With Diroximel Fumarate (DRF) in Adult… Ended

2022-502552-31-00 Relapsing Forms of Multiple Sclerosis 4 2023-10-03
A Phase 3, Open-label Study of Adjunctive Ganaxolone (GNX) Treatment in Children and Adults with Tuberous Sclerosis Complex (TSC)-related Ep… Ended

2022-503067-15-00 Tuberous Sclerosis Complex (TSC) related epilepsy 5 2023-10-02
Open label, single-center, cross-over randomized, relative bioavailability study comparing 4 new BF2.649 (pitolisant) tablet formulations ve… Ended

2023-505769-98-00 Narcolepsy 3 2023-09-26
A Pilot Open-label, Randomized, Crossover, Comparative Bioavailability Study of Levodopa Administered via Levodopa Cyclops™ (test product) R… Ended

2023-504687-42-00 No therapeutic indication in the current trial with hea 3 2023-09-19
A Phase 1/2 Randomized, Blinded, Dose-escalation Study to Evaluate the Safety and Efficacy of Intrathecal Administration of AAV9-ABCD1 Gene … Ended

2024-518451-39-00 Adrenomyeloneuropathy 1 2023-09-19
Study to Assess Adverse Events, Change in Disease Activity and How Oral ABBV-552 Capsules Moves Through the Body of Participants Aged 50 to … Ended

2022-501918-55-00 Mild Alzheimer's disease 4 2023-09-12
Evaluation of sensory testing to measure the effects of tetrodotoxin Ended

2022-500318-24-00 pain 4 2023-08-30