Digestive System Diseases

633 trials 301 recruiting

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Essentiale® liquid once-daily Phase III study Recruiting

2025-521678-32-00 MASLD (Metabolic Dysfunction-Associated Steatotic Liver 5 2026-03-03
EASE SBS 5 (Efficacy And Safety Evaluation of Glepaglutide in Treatment of SBS) Recruiting

2024-512486-14-00 Short Bowel Syndrome 5 2026-01-22
Adjuvant chemotherapy for prevention of recurrence in patients with detectable ctDNA after surgery in high-riskrectal cancer. Recruiting

2024-517700-12-00 Rectal cancer 5 2025-12-10
Randomized phase 2 study of Simvastatin in patients with ARID1A mutated advanced gastrooesophageal carcinoma treated with Nivolumab and Oxal… Recruiting

2024-519591-39-00 advanced or metastatic gastrooesophageal carcinoma HER2 4 2025-11-11
A Study to Assess the Adverse Events, Effectiveness, and How the Drug Moves through the Body of Intravenous and Subcutaneous Injections of R… Recruiting

2024-514695-41-00 Ulcerative Colitis 5 2025-10-17
Vedolizumab Subcutaneous Long-term Open-label Extension Study in Pediatric Subjects Recruiting

2023-508804-39-00 Ulcerative Colitis or Crohn’s Disease 5 2025-10-15
A clinical study of MK-7240 for the treatment of Crohn’s disease (MK-7240-008) Recruiting

2024-518296-56-00 Crohn’s Disease 5 2025-09-29
A study to investigate efficacy and safety of brivekimig in participants with Crohn’s disease Recruiting

2024-517016-30-00 Crohn’s disease 4 2025-09-26
Dose-Selection, Safety and Efficacy Study with Open-Label Extension of Choline Chloride for Injection in Adolescent and Adult Patients with … Recruiting

2024-519496-26-00 Intestinal Failure 10 2025-09-25
Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obe… Recruiting

2024-520209-38-00 Obesity or Overweight 5 2025-09-19
A Phase 2a Study of the Safety and Efficacy of OD-07656 and of Subsequent Vedolizumab Therapy in Moderately to Severely Active Ulcerative Co… Recruiting

2024-520201-39-00 Moderately to Severely Active Ulcerative Colitis 4 2025-08-28
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics o… Recruiting

2024-520202-19-00 Subjects with Intestinal Failure-Associated Liver Disea 4 2025-08-19
Sotorasib combined with first-line chemotherapy for advanced pancreatic adenocarcinoma Recruiting

2024-516233-12-00 Advanced pancreatic adenocarcinoma 3 2025-08-08
AFFIRM: A Randomized, Double-Blind, Placebo-Controlled, Study to Evaluate the Effect of Seladelpar on Clinical Outcomes in Patients with Pri… Recruiting

2024-516525-31-01 Primary Biliary Cholangitis 5 2025-07-14
BreAK CRC (001) trial Recruiting

2024-512011-45-00 Unresectable locally advanced or metastatic colorectal 7 2025-06-17
A study evaluating the effects of filgotinib in children and teenagers with ulcerative colitis Recruiting

2024-511458-32-00 Ulcerative colitis 5 2025-06-15
A Study to Assess the Effectiveness and Safety of Induction Therapy with RO7790121 in Participants with Moderately to Severely Active Crohn'… Recruiting

2024-513054-30-00 Moderately to Severely Active Crohn's Disease (CD) 5 2025-04-16
An Adaptive, Dose-Ranging, Phase 2 Study of Eltrekibart Given Alone or in Combination with Mirikizumab for the Treatment of Adult Patients w… Recruiting

2023-507853-13-00 Ulcerative Colitis 4 2025-02-25
Phase II randomized trial to assess the effect of intensive vs standard adjuvant chemotherapy in localised colon cancer with circulating tum… Recruiting

2024-518131-11-02 Localised Colon Cancer (stage II-III) 4 2025-01-24
A multi-centred, partially randomised, patient-preference trial of radical surgery versus adjuvant chemoradiotherapy after local excision fo… Recruiting

2024-517410-15-01 Rectal cancer 5 2025-01-14
SILVER-study Recruiting

2024-517502-28-01 Inflammatory bowel disease 6 2025-01-14
Phase 3 Study of Vedolizumab Subcutaneous in Pediatric Subjects With Moderately to Severely Active Ulcerative Colitis or Crohn’s Disease Recruiting

2023-503188-40-00 Active Ulcerative Colitis or Crohn’s Disease 5 2025-01-06
COLLISION RELAPSE trial Recurrent colorectal liver metastases: repeat local treatment +/- neoadjuvant systemic therapy, a phase III prospect… Recruiting

2024-515341-41-01 Colorectal liver metastases 11 2024-12-11
Clinical trial of MDNA11 (investigational drug) administered alone or in combination with pembrolizumab (immune checkpoint inhibitor) in Pat… Recruiting

2023-507536-21-00 Advanced Solid Tumors 7 2024-10-04