Musculoskeletal Diseases

438 trials 179 recruiting

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A phase 2 trial assessing Ifenprodil as a ReMyelinating repurpOsed Drug in Multiple Sclerosis – MODIF-MS Halted

2023-507874-42-00 Multiple sclerosis 9 2024-08-27
A Gene Transfer Therapy Study to Evaluate the Safety and Efficacy of Delandistrogene Moxeparvovec (SRP-9001) in Non-Ambulatory and Ambulator… Halted

2024-512626-28-00 Duchenne Muscular Dystrophy 5 2024-03-28
Study to assess the safety and expression of RO7494222 (SRP-9001) in participants under the age of 4 with Duchenne muscular dystrophy Halted

2023-509901-57-00 Duchenne Muscular Dystrophy 4 2023-10-26
An open label, randomized, single-dose, two-treatment, two-period, cross-over bioequivalence study comparing Pyridostigmine Bromide, P.R.Tab… Ended

2025-524218-27-00 treatment of myasthenia gravis 2 2026-01-21
Open label study to investigate patch adhesion of an Esflurbiprofen-containing patch in healthy volunteers Ended

2025-523577-42-00 Patch adhesion trial with healthy subjects, therapeutic 3 2026-01-06
An open label, randomized, single-dose, two-treatment, two-period, cross-over bioequivalence study comparing Pyridostigmine Bromide, P.R.Tab… Ended

2025-524217-89-00 treatment of myasthenia gravis 2 2025-12-04
A randomised, open label, three periods, three-treatment crossover study to evaluate the pharmacokinetics of alendronic acid oral formulatio… Ended

2025-522606-20-00 Pharmacokinetic study in healthy volunteers under faste 3 2025-10-06
A prospective, double-blinded, randomized, placebo-controlled phase 1/2a study to assess safety, tolerability, systemic exposure and prelimi… Ended

2024-517920-21-00 knee osteoarthritis 9 2025-08-19
The effects of 2-week long treatment with naproxen sodium (Nalgesin® Forte) on synovial fluid cytokine and naproxen concentration and clinic… Ended

2023-505875-56-00 Knee osteoarthritis 6 2025-05-21
An open label, randomized, single-dose, two-treatment, two-period, cross-over pilot bioequivalence study comparing Pyridostigmine Bromide, P… Ended

2025-521177-14-00 treatment of myasthenia gravis 2 2025-05-15
A Randomized, Double-Blind, Multi-Center, Placebo-Controlled, Trial to Evaluate the Efficacy and Safety of Once Daily Diclofenac Gel AMZ001 … Ended

2024-517404-11-00 Knee Osteoarthritis 5 2025-04-30
A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharma… Ended

2023-506723-28-00 Mitochondrial encephalomyopathy, lactic acidosis and st 4 2025-03-20
A study to evaluate safety and efficacy of Empasiprubart in adults with Dermatomyositis Ended

2023-508337-14-00 Myositis, Dermatomyositis 4 2025-03-18
A study to Learn If Study Medicines Called Cyclosporine and Clarithromycin Affect How the Body Processes the Other Study Medicine Called PF-… Ended

2024-520126-11-00 Heart Failure 3 2025-03-14
Randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of an Esflurbiprofen Topical System (EFTS) vs. … Ended

2024-513063-45-00 Acute ankle sprains grade I 5 2025-03-06
A randomised, open label, single dose, two periods, crossover study of the comparative pharmacokinetics of two alendronic acid formulations … Ended

2024-519666-43-00 not applicable (submitted trial is a pharmacokinetic st 3 2025-03-04
A Randomized, Four-Way Change-over Study to Evaluate the Effect of Moderate Heat, Occlusion, and Moderate Exercise on the Pharmacokinetics a… Ended

2024-513059-33-00 bioavailability trial with healthy volunteers, therapeu 3 2025-02-12
An open-label, multi-centric trial to assess the safety and efficacy of an Esflurbiprofen Topical System (EFTS) in the local symptomatic and… Ended

2024-513064-26-00 acute contusion of the upper or lower limbs 5 2025-02-12
A study in subjects with gout flares that investigates the effect, safety, tolerability, and pharmacokinetics (absorption, distribution, met… Ended

2023-508793-29-00 Gout flares 3 2025-01-07
Characterisation of availability in the body of the active substance(s) of the newly developed patch Esflurbiprofen Topical System (EFTS) in… Ended

2024-513058-31-00 bioavailability and patch adhesion trial with healthy v 3 2025-01-07
A Phase 2 open-label imaging study to explore the effects of sonelokimab in patients with active axial spondyloarthritis Ended

2024-513498-36-00 axial spondyloarthritis 4 2024-12-23
A relative bioavailability study between a fixed dose combination product of Ibuprofen and Paracetamol vs. free combination of Ibuprofen a… Ended

2024-516423-14-00 cold and flu 2 2024-12-19
A Randomized, Placebo-Controlled, Double-Blind, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Subcutaneous CT-P13 in … Ended

2024-510945-32-00 Rheumatoid arthritis 5 2024-12-17
A study to establish the bioequivalence of free acid tafamidis 61 mg capsule and tablet, and evaluate the safety and tolerability of the 61 … Ended

2024-514166-40-00 Transthyretin amyloidosis 2 2024-12-16